Bioactivity-guided isolation of cytotoxic and antioxidant phytochemicals from four Cousinia species from stenocephala bunge section

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dc.contributor.authorPasayeva, Leyla.
dc.contributor.authorÜstün, Osman.
dc.contributor.authorDemirpolat, Eren.
dc.contributor.authorKaratoprak, Gökçe S.
dc.contributor.authorTugay, Osman.
dc.contributor.authorKosar, Müberra.
dc.date.accessioned2020-03-26T20:12:44Z
dc.date.available2020-03-26T20:12:44Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümüen_US
dc.description.abstractBackground: Asteraceae family contains several cytotoxic compounds bearing genus. Cousinia genus is included in the Asteraceae; it has not been studied phytochemically in detail. Objective: In this study, chemical compositions of four Cousinia species (Cousinia davisiana [CD], Cousinia foliosa, Cousinia ramosissima, and Cousinia stenocephala [CS]) were evaluated according to their cytotoxic and antioxidant effects using bioactivity-guided isolation. Materials and Methods: The cytotoxic effect was investigated with Sulphorhodamine B method against Colo205 (human colon carcinoma), A549 (human non- small cell lung cancer) cell lines, and antioxidant activity tested with 1,1-diphenyl-2-picrylhydrazyl, 2,2' azino-bis 3-ethylbenzothiazoline-6-sulphonic acid scavenging tests, and beta-carotene/linoleic acid co-oxidation test. Purified compounds were elucidated by one-dimensional and two-dimensional nuclear magnetic resonance and mass spectroscopic techniques. The quantitative and qualitative determination of unpurified compounds within the extracts was carried out by liquid chromatography-mass spectrometry/mass spectrometry. Results: CS methanol extract, dichloromethane subextract, and FR-3 showed more cytotoxicity; isolated compound (psi-taraxasterol) showed no cytotoxic activity. CD methanol extract and n-butanol subextract showed significant antioxidant activity. Conclusion: This is the first report that these phytochemical compounds were identified in Cousinia genus, and it is thought that these compounds could contribute to the chemotaxonomy of the genus.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [116S115]en_US
dc.description.sponsorshipWe would like to acknowledge the financial support given by the Scientific and Technological Research Council of Turkey (TUBITAK, project number 116S115).en_US
dc.identifier.citationPasayeva, L., Üstün, O., Demirpolat, E., Karatoprak, G. S., Tugay, O., Kosar, M. (2019). Bioactivity-Guided Isolation of Cytotoxic and Antioxidant Phytochemicals from Four Cousinia Species from Stenocephala Bunge Section. Pharmacognosy Magazine, 15(65), 682-692.
dc.identifier.doi10.4103/pm.pm_487_18en_US
dc.identifier.endpage692en_US
dc.identifier.issn0973-1296en_US
dc.identifier.issn0976-4062en_US
dc.identifier.issue65en_US
dc.identifier.startpage682en_US
dc.identifier.urihttps://dx.doi.org/10.4103/pm.pm_487_18
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37534
dc.identifier.volume15en_US
dc.identifier.wosWOS:000487554500022en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorTugay, Osman.
dc.language.isoenen_US
dc.publisherWOLTERS KLUWER MEDKNOW PUBLICATIONSen_US
dc.relation.ispartofPHARMACOGNOSY MAGAZINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAntioxidanten_US
dc.subjectCousiniaen_US
dc.subjectcytotoxicityen_US
dc.subjectliquid chromatography-mass spectrometry/mass spectrometryen_US
dc.subjectnuclear magnetic resonanceen_US
dc.titleBioactivity-guided isolation of cytotoxic and antioxidant phytochemicals from four Cousinia species from stenocephala bunge sectionen_US
dc.typeArticleen_US

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