Effects of Curcumin on the Changes in Some Acute Phase Proteins in Aflatoxin B1 Applied Rats
Yükleniyor...
Dosyalar
Tarih
2020 Aralık
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Selçuk Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This research was carried out to evaluate the possible effects of curcumin on acute phase proteins in aflatoxin applied rats.
In the study, 38 healthy male Wistar Albino rats were used. Group I animals was no applied. Animals in Group II were orally
given 1 ml 10% DMSO daily for 60 days. Animals in Group III were orally given 300 mg/kg curcumin dissolved in 10% DMSO
daily for 60 days. Animals in Group IV were orally given 250 µg/kg aflatoxin B1 dissolved in 10% DMSO daily for 60 days.
Animals in Group V was orally given 250 µg/kg aflatoxin B1 dissolved in 10% DMSO and 300 mg/kg curcumin dissolved in
10% DMSO daily for 60 days. At the end of the study, nitric oxide, amyloid-A, haptoglobin and ceruloplasmin were determined
in blood samples taken from all animals. In this study, nitric oxide, amyloid-A, haptoglobin and ceruloplasmin levels with
aflatoxin B1 administration were found to be significantly higher than the control group (p<0.05). In the group in which
aflatoxin and curcumin were administered together, nitric oxide, amyloid-A, haptoglobin and ceruloplasmin levels were lower
than in the aflatoxin group (p<0.05). In conclusion, the obtained data indicated that administration of curcumin may be useful
to alleviate the abnormalities in acute phase proteins resulting from aflatoxicosis.
Açıklama
Anahtar Kelimeler
Aflatoxin, Curcumin, Amyloid-A, Haptoglobin, Rats
Kaynak
Turkish Journal of Sport and Exercise
WoS Q Değeri
Scopus Q Değeri
Cilt
22
Sayı
3
Künye
Uluışık, D., Keskin, E., Hatipoğlu, D., (2020). Effects of Curcumin on the Changes in Some Acute Phase Proteins in Aflatoxin B1 Applied Rats. Turkish Journal of Sport and Exercise, 22(3), 384-388.
DOI: 10.15314/tsed.735635
