Effects of Curcumin on the Changes in Some Acute Phase Proteins in Aflatoxin B1 Applied Rats

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dc.authorid0000-0003-1462-0836en_US
dc.authorid0000-0003-3839-0414en_US
dc.authorid0000-0003-3790-7821en_US
dc.contributor.authorUluışık, Deniz
dc.contributor.authorKeskin, Ercan
dc.contributor.authorHatipoğlu, Durmuş
dc.date.accessioned2023-08-16T16:58:14Z
dc.date.available2023-08-16T16:58:14Z
dc.date.issued2020 Aralıken_US
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Temel Bilimler Bölümüen_US
dc.description.abstractThis research was carried out to evaluate the possible effects of curcumin on acute phase proteins in aflatoxin applied rats. In the study, 38 healthy male Wistar Albino rats were used. Group I animals was no applied. Animals in Group II were orally given 1 ml 10% DMSO daily for 60 days. Animals in Group III were orally given 300 mg/kg curcumin dissolved in 10% DMSO daily for 60 days. Animals in Group IV were orally given 250 µg/kg aflatoxin B1 dissolved in 10% DMSO daily for 60 days. Animals in Group V was orally given 250 µg/kg aflatoxin B1 dissolved in 10% DMSO and 300 mg/kg curcumin dissolved in 10% DMSO daily for 60 days. At the end of the study, nitric oxide, amyloid-A, haptoglobin and ceruloplasmin were determined in blood samples taken from all animals. In this study, nitric oxide, amyloid-A, haptoglobin and ceruloplasmin levels with aflatoxin B1 administration were found to be significantly higher than the control group (p<0.05). In the group in which aflatoxin and curcumin were administered together, nitric oxide, amyloid-A, haptoglobin and ceruloplasmin levels were lower than in the aflatoxin group (p<0.05). In conclusion, the obtained data indicated that administration of curcumin may be useful to alleviate the abnormalities in acute phase proteins resulting from aflatoxicosis.en_US
dc.identifier.citationUluışık, D., Keskin, E., Hatipoğlu, D., (2020). Effects of Curcumin on the Changes in Some Acute Phase Proteins in Aflatoxin B1 Applied Rats. Turkish Journal of Sport and Exercise, 22(3), 384-388. DOI: 10.15314/tsed.735635en_US
dc.identifier.doi10.15314/tsed.735635en_US
dc.identifier.endpage388en_US
dc.identifier.issn2147-5652
dc.identifier.issue3en_US
dc.identifier.startpage384en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/49505
dc.identifier.volume22en_US
dc.institutionauthorUluışık, Deniz
dc.institutionauthorKeskin, Ercan
dc.institutionauthorHatipoğlu, Durmuş
dc.language.isoenen_US
dc.publisherSelçuk Üniversitesien_US
dc.relation.ispartofTurkish Journal of Sport and Exerciseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAflatoxinen_US
dc.subjectCurcuminen_US
dc.subjectAmyloid-Aen_US
dc.subjectHaptoglobinen_US
dc.subjectRatsen_US
dc.titleEffects of Curcumin on the Changes in Some Acute Phase Proteins in Aflatoxin B1 Applied Ratsen_US
dc.typeArticleen_US

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