Evaluation of Oxidative Stress in Women with Polycystic Ovarian Syndrome as Represented by Serum Ischemia Modified Albumin and Its Correlation with Testosterone and Insulin Resistance

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dc.contributor.authorBeyazit, Fatma
dc.contributor.authorYilmaz, Nafiye
dc.contributor.authorBalci, Osman
dc.contributor.authorAdam, Magdi
dc.contributor.authorYaman, Selen Taflan
dc.date.accessioned2020-03-26T19:24:06Z
dc.date.available2020-03-26T19:24:06Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective Ischemia-mediated oxidative stress and inflammation have been reported to be important contributors to the pathogenesis of polycystic ovary syndrome (PCOS). Ischemia-modified albumin (IMA) is a novel marker generated under ischemic and oxidative conditions and may reflect disease activity in distinct disease states. Therefore, we investigated whether the serum IMA levels are affected in infertile PCOS patients. Methods Forty-six patients with infertile PCOS, 30 patients with unexplained infertility, and 31 age-and body mass index (BMI)-matched controls were included in this cross-sectional study. Biochemical parameters, serum IMA levels, and their correlations with serum testosterone and insulin resistance were determined for each subject. Results In patients with infertile PCOS, the serum IMA levels were significantly elevated (p=0.003) compared with unexplained infertility patients and controls. A correlation analysis suggested that the IMA levels only correlated with the serum free testosterone levels in PCOS patients (r=0.43, p=0.028). Conclusion Elevations in the serum IMA levels in infertile PCOS patients may suggest a possible additional role of oxidative stress mechanisms in disease pathophysiology. Moreover, correlation between serum IMA and testosterone levels may influence the quality of oocytes via alterations in the balance of critical follicular fluid factors in the follicular microenvironment.en_US
dc.identifier.doi10.2169/internalmedicine.55.6265en_US
dc.identifier.endpage2364en_US
dc.identifier.issn0918-2918en_US
dc.identifier.issn1349-7235en_US
dc.identifier.issue17en_US
dc.identifier.pmid27580534en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2359en_US
dc.identifier.urihttps://dx.doi.org/10.2169/internalmedicine.55.6265
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33578
dc.identifier.volume55en_US
dc.identifier.wosWOS:000383017300005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJAPAN SOC INTERNAL MEDICINEen_US
dc.relation.ispartofINTERNAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectpolycystic ovary syndromeen_US
dc.subjectunexplained infertilityen_US
dc.subjectischemia-modified albuminen_US
dc.subjectinsulinen_US
dc.subjecttestosteroneen_US
dc.titleEvaluation of Oxidative Stress in Women with Polycystic Ovarian Syndrome as Represented by Serum Ischemia Modified Albumin and Its Correlation with Testosterone and Insulin Resistanceen_US
dc.typeArticleen_US

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