Relation of serum leptin and insulin-like growth factor-1 levels to intima-media thickness and functions of common carotid artery in children and adolescents with type 1 diabetes

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dc.contributor.authorAtabek, ME
dc.contributor.authorKurtoglu, S
dc.contributor.authorDemir, F
dc.contributor.authorBaykara, M
dc.date.accessioned2020-03-26T16:55:26Z
dc.date.available2020-03-26T16:55:26Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground and aim: Leptin and insulin-like growth factor-1 (IGF-1) have been suggested to be involved in the pathogenesis of atherosclerosis. The aim of this study was to evaluate the relationship between serum leptin, IGF-1 and intima-media thickness (IMT) and functions of common carotid artery (CCA) in children and adolescent patients with type 1 diabetes. Material and methods: Serum leptin and IGF-1 levels were measured in 45 diabetic patients (23 girls and 22 boys). Age, diabetes duration as well as major cardiovascular risk factors, including anthropometric and metabolic parameters, were matched between girls and boys. The relation of serum leptin and IGF-1 levels to CCA structure and functions were measured by ultrasonography as IMT, cross-sectional compliance (CSC), cross-sectional distensibility (CSD), diastolic wall stress (DWS) and incremental elastic modulus (IEM). Results: Serum leptin levels of diabetic girls were higher than those in the boys (21.8 +/- 14.5 mug/l vs 8.9 +/- 10.6 mug/l, p = 0.002). However, the difference for serum IGF-1 levels was not significant between diabetic girls and boys (240.7 +/- 96.8 ng/ml vs 234.7 +/- 93.2 ng/ml; p > 0.05). In all subjects, leptin levels were correlated with CSC (p = 0.04), CSD (p = 0.04) and IEM (p = 0.01), and IGF-I levels were only correlated with CSC (p = 0.01). Leptin did not show any correlation with ultrasonographic measurements in both girls and boys separately. IGF-1 was correlated with CSC (p = 0.001), CSD (p = 0.002) and IEM (p < 0.001) in boys but not in girls. In a multivariate regression model, IGF-1 emerged as independent correlates for mean CSD and IEM in boys but not in girls. Conclusion: Serum leptin and IGF-1 levels in children and adolescent patients with type 1 diabetes are associated with functions of common carotid artery, and the association of IGF-1 levels is influenced by sex.en_US
dc.identifier.doi10.1111/j.1651-2227.2004.tb02717.xen_US
dc.identifier.endpage1057en_US
dc.identifier.issn0803-5253en_US
dc.identifier.issn1651-2227en_US
dc.identifier.issue8en_US
dc.identifier.pmid15456195en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1052en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1651-2227.2004.tb02717.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19183
dc.identifier.volume93en_US
dc.identifier.wosWOS:000222671200011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofACTA PAEDIATRICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectatherosclerosisen_US
dc.subjectcommon carotid arteryen_US
dc.subjectIGF-1en_US
dc.subjectleptinen_US
dc.subjecttype 1 diabetesen_US
dc.titleRelation of serum leptin and insulin-like growth factor-1 levels to intima-media thickness and functions of common carotid artery in children and adolescents with type 1 diabetesen_US
dc.typeArticleen_US

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