Serum cytokine and chemokine profiles in patients with alopecia areata

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dc.contributor.authorBilgic, O.
dc.contributor.authorSivrikaya, A.
dc.contributor.authorUnlu, A.
dc.contributor.authorAltinyazar, H. C.
dc.date.accessioned2020-03-26T19:26:16Z
dc.date.available2020-03-26T19:26:16Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Most evidence supports the role of altered T cell-mediated immunity in the pathogenesis of alopecia areata (AA). Tough cytokines and chemokines play an important role in the immune process of AA, their expressions have been examined in limited studies. Objective: To determine serum cytokine levels of TNF-alpha, IL-6, and IL-23, and some of the Th1-(CXCL9), Th2-(CCL17), and Th17-associated (CCL20 and CCL27) chemokines in patients with AA. Methods: Forty patients with AA and 40 healthy controls were enrolled in the study. Serum concentrations of cytokines and chemokines were measured using enzyme-linked immunoassay techniques. Results: The mean serum levels of TNF-alpha, IL-6, IL-23, CXCL9, CCL17, CCL20, and CCL27 in AA patients were significantly higher than in the controls. However, with logistic regression analyses, only CCL17 and CCL27 levels showed a positive relationship, and IL-23 levels showed a negative relationship, with the presence of AA. Furthermore, serum CCL27 levels were positively correlated with AA severity. Conclusion: This study suggests that CCL17 and CCL27 may have an aggravating effect, whereas IL-23 may have a protective effect for the development of AA. Additionally, serum CCL27 levels may be useful as marker of disease severity.en_US
dc.identifier.doi10.3109/09546634.2015.1093591en_US
dc.identifier.endpage263en_US
dc.identifier.issn0954-6634en_US
dc.identifier.issn1471-1753en_US
dc.identifier.issue3en_US
dc.identifier.pmid26367497en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage260en_US
dc.identifier.urihttps://dx.doi.org/10.3109/09546634.2015.1093591
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33981
dc.identifier.volume27en_US
dc.identifier.wosWOS:000372193700014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofJOURNAL OF DERMATOLOGICAL TREATMENTen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectalopecia areataen_US
dc.subjectproinflammatory markersen_US
dc.subjectCytokinesen_US
dc.subjectchemokinesen_US
dc.titleSerum cytokine and chemokine profiles in patients with alopecia areataen_US
dc.typeArticleen_US

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