Follicle-stimulating hormone receptor gene polymorphisms in women with endometriosis

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dc.contributor.authorKerimoglu, Ozlem Secilmis
dc.contributor.authorYilmaz, Setenay Arzu
dc.contributor.authorPekin, Aybike
dc.contributor.authorNergiz, Suleyman
dc.contributor.authorIncesu, Feyzanur
dc.contributor.authorDogan, Nasuh Utku
dc.contributor.authorAcar, Hasan
dc.date.accessioned2020-03-26T19:06:01Z
dc.date.available2020-03-26T19:06:01Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe purpose of this study was to evaluate the influence of the follicle-stimulating hormone (FSH) receptor poymorphisms Asn680Ser and Thr307Ala on endometriosis in Turkish women. Polymorphic analysis of the FSH receptor gene was performed in 100 patients with endometriosis and 100 controls. Genomic DNA was obtained from peripheral blood leukocytes and polymorphisms were investigated using restriction fragment length polymorphism analysis. There were no significant differences in genotype frequencies of FSH receptor gene between endometriosis patients and controls. When the patients were divided into two groups according to disease severity, we found that the patients with the SS (680 Ser/Ser) or AA (307 Ala/Ala) genotype were less likely to develop stage 3-4 endometriosis compared to the stage 1-2 endometriosis group (P = 0.004; OR: 0.177, 95 % CI 0.055-0.568 and P = 0.040; OR: 0.240, 95 % CI 0.061-0.938; respectively). The distributions of FSHR polymorphisms may not have an effect on endometriosis development but they are associated with the severity of the disease. The polymorphisms encoding SS at the position 680 and AA at the position 307 and the patients with the genotype that included alanine or serine were less likely to develop stage 3-4 endometriosis compared to the stage 1-2 endometriosis group.en_US
dc.description.sponsorshipSelcuk UniversitySelcuk Universityen_US
dc.description.sponsorshipThis study was supported by Selcuk University Scientific Projects fund.en_US
dc.identifier.doi10.1007/s00404-014-3562-4en_US
dc.identifier.endpage1416en_US
dc.identifier.issn0932-0067en_US
dc.identifier.issn1432-0711en_US
dc.identifier.issue6en_US
dc.identifier.pmid25502184en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1411en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00404-014-3562-4
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32175
dc.identifier.volume291en_US
dc.identifier.wosWOS:000354226800034en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGER HEIDELBERGen_US
dc.relation.ispartofARCHIVES OF GYNECOLOGY AND OBSTETRICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectEndometriosisen_US
dc.subjectFollicle-stimulating hormone receptoren_US
dc.subjectPolymorphismen_US
dc.subjectRestriction fragment length polymorphism analysisen_US
dc.titleFollicle-stimulating hormone receptor gene polymorphisms in women with endometriosisen_US
dc.typeArticleen_US

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