Effects of Preoperative Oral Melatonin Medication on Postoperative Analgesia, Sleep Quality, and Sedation in Patients Undergoing Elective Prostatectomy: A Randomized Clinical Trial

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dc.contributor.authorBorazan, Hale
dc.contributor.authorTuncer, Sema
dc.contributor.authorYalçın, Naime
dc.contributor.authorErol, Atilla
dc.contributor.authorOtelcioğlu, Şeref
dc.date.accessioned2020-03-26T17:48:19Z
dc.date.available2020-03-26T17:48:19Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose Our intention was to assess the effectiveness of preoperative oral melatonin medication on sedation, sleep quality, and postoperative analgesia in patients undergoing elective prostatectomy. Fifty-two ASA I-II patients undergoing elective prostatectomy were included in this study, randomly divided into two groups. Patients received an oral placebo (n = 26) or 6 mg melatonin (n = 26) the night before and 1 h before surgery. All patients received a standard anesthetic protocol. At the end of surgery, all patients received tramadol i.v. via a PCA device. Extubation time, intraoperative fentanyl consumption, and recovery time were assessed at the end of the operation. Pain scores, tramadol consumption, and sedation scores were assessed at 1, 2, 4, 6, 12, 18, and 24 h postoperatively, and sleep quality and subjective analgesic efficacy were assessed at 24 h after surgery. There were no significant differences in demographic data between the groups. Extubation time and recovery time from anesthesia were significantly longer in the melatonin group (P < 0.05). Intraoperative fentanyl usage, pain scores, and tramadol consumption were significantly lower in the melatonin group (P < 0.05). The postoperative sleep quality of patients was significantly better in the melatonin group than in the control group (P < 0.05). Postoperative VAS of pain was significantly lower in the melatonin group compared with the control group at 1, 2, 4, 6, 12, 18, and 24 h postoperatively (P < 0.05). Subjective analgesic efficacy of patients was significantly different between groups (P < 0.05). The sedation scores were significantly higher in the melatonin group than in the control group at 1 h and 2 h after surgery (P < 0.05). Preoperative oral melatonin administration decreased pain scores and tramadol consumption and enhanced sleep quality, sedation scores, and subjective analgesic efficacy during the postoperative period.en_US
dc.identifier.citationBorazan, H., Tuncer, S., Yalçın, N., Erol, A., Otelcioğlu, Ş., (2010). Effects of Preoperative Oral Melatonin Medication on Postoperative Analgesia, Sleep Quality, and Sedation in Patients Undergoing Elective Prostatectomy: A Randomized Clinical Trial. Journal of Anesthesia, (24), 155-160. Doi: 10.1007/s00540-010-0891-8
dc.identifier.doi10.1007/s00540-010-0891-8en_US
dc.identifier.endpage160en_US
dc.identifier.issn0913-8668en_US
dc.identifier.pmid20186437en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage155en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00540-010-0891-8
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24863
dc.identifier.volume24en_US
dc.identifier.wosWOS:000276660500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBorazan, Hale
dc.institutionauthorTuncer, Sema
dc.institutionauthorYalçın, Naime
dc.institutionauthorErol, Atilla
dc.institutionauthorOtelcioğlu, Şeref
dc.language.isoenen_US
dc.publisherSpringer Tokyoen_US
dc.relation.ispartofJournal of Anesthesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMelatoninen_US
dc.subjectPostoperative analgesiaen_US
dc.subjectSedationen_US
dc.subjectTramadolen_US
dc.subjectGeneral anesthesiaen_US
dc.titleEffects of Preoperative Oral Melatonin Medication on Postoperative Analgesia, Sleep Quality, and Sedation in Patients Undergoing Elective Prostatectomy: A Randomized Clinical Trialen_US
dc.typeArticleen_US

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