A Possible Mechanism of X-Ray-İnduced Injury in Rat Lens

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dc.contributor.authorAvunduk, Avni Murat
dc.contributor.authorYardımcı, Serdar
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorKurnaz, Levent
dc.contributor.authorCengiz, Mustafa
dc.date.accessioned2020-03-26T16:36:11Z
dc.date.available2020-03-26T16:36:11Z
dc.date.issued2000
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose: X-ray and other radiation can cause cataract, but the pathogenic mechanism is largely unknown. The aim of this study was to investigate the accumulation of iron in the x-ray-exposed rat lens and its relationship to lens injury. Methods: Fifty male Wistar rats were divided randomly into five groups of 10. Groups 2 and 4 rats were sham-exposed, groups 3 and 5 were x-ray-treated, and group 1 served as control. X-ray radiation and sham exposure were performed in a similar manner. After 10 and 30 days of exposure, a lens from each rat in groups 2 and 3, and 3 and 5, respectively, were analyzed by flame atomic absorption technique for the assessment of metal content. Results: Significantly decreased zinc and increased iron and calcium concentrations were detected in the lens samples of groups 3 and 5 compared with groups 2 and 4 and controls. Similar results were obtained comparing groups 5 and 3. Conclusions: We propose that x-ray exposure may cause toxic cell injury of the rat lens via Fenton metals catalyzed damage. initial lens membrane damage in the radiolytic phase may permit the access of iron resulting in lens damage.en_US
dc.identifier.citationAvunduk, A. M., Yardımcı, S., Avunduk, M. C., Kurnaz, L., Cengiz, M., (2000). A Possible Mechanism of X-Ray-İnduced Injury in Rat Lens. Japanese Journal of Ophthalmology, 44(1), 88-91. Doi: 10.1016/S0021-5155(99)00169-0
dc.identifier.doi10.1016/S0021-5155(99)00169-0en_US
dc.identifier.endpage91en_US
dc.identifier.issn0021-5155en_US
dc.identifier.issue1en_US
dc.identifier.pmid10698031en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage88en_US
dc.identifier.urihttps://dx.doi.org/10.1016/S0021-5155(99)00169-0
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17178
dc.identifier.volume44en_US
dc.identifier.wosWOS:000084804200014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAvunduk, Mustafa Cihat
dc.language.isoenen_US
dc.publisherSpringer Tokyoen_US
dc.relation.ispartofJapanese Journal of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcalciumen_US
dc.subjectcataracten_US
dc.subjectironen_US
dc.subjectraten_US
dc.subjectx-rayen_US
dc.titleA Possible Mechanism of X-Ray-İnduced Injury in Rat Lensen_US
dc.typeArticleen_US

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