Relationship between P561T and C422F polymorphisms in growth hormone receptor gene and mandibular prognathism

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dc.contributor.authorBayram, Sinem
dc.contributor.authorBasciftci, Faruk Ayhan
dc.contributor.authorKurar, Ercan
dc.date.accessioned2020-03-26T18:58:27Z
dc.date.available2020-03-26T18:58:27Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: To evaluate the allele and genotype frequencies of the P561T and C422F polymorphic sites of the growth hormone receptor (GHR) gene and the relationship between mandibular prognathism (MP) and these two single-nucleotide polymorphisms (SNPs). Materials and Methods: A total of 99 subjects with severe skeletal Class III MP who planned to undergo orthognathic surgery and 99 subjects with Class I occlusion were examined in this study to evaluate the relationship between MP and two SNPs in exon 10 of the GHR gene. GHR was chosen as a candidate gene because growth hormone plays an important role in cartilage growth. A blood sample was used to extract genomic DNA, and the polymerase chain reaction restriction fragment length polymorphism method was used to determine genotypes of P561T and C422F. The Minitab 14.0 packet program was used to perform statistical analysis. Results: Allele frequencies of the C422F and P561T variants were determined. Because of the low allele frequency of the control group, statistical analysis could not be performed to test the difference between MP and control groups. Therefore, the data were combined to determine the association between the P561T polymorphism and craniofacial measurements. Effective mandibular length (condylion-gnathion) and lower face height (anterior nasal spina-menton) were associated with the P561T variant. Conclusion: This finding supports that the GHR might be a candidate gene for mandibular morphogenesis in this population.en_US
dc.description.sponsorshipSelcuk UniversitySelcuk University [11202032]en_US
dc.description.sponsorshipThis study was produced from the PhD thesis of Sinem Bayram and supported by Selcuk University Research Projects (11202032).en_US
dc.identifier.doi10.2319/091713-680.1en_US
dc.identifier.endpage809en_US
dc.identifier.issn0003-3219en_US
dc.identifier.issn1945-7103en_US
dc.identifier.issue5en_US
dc.identifier.pmid24654940en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage803en_US
dc.identifier.urihttps://dx.doi.org/10.2319/091713-680.1
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31108
dc.identifier.volume84en_US
dc.identifier.wosWOS:000341225800007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE H ANGLE EDUCATION RESEARCH FOUNDATION, INCen_US
dc.relation.ispartofANGLE ORTHODONTISTen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMandibular prognathismen_US
dc.subjectSingle-nucleotide polymorphismen_US
dc.subjectGrowth hormone receptoren_US
dc.titleRelationship between P561T and C422F polymorphisms in growth hormone receptor gene and mandibular prognathismen_US
dc.typeArticleen_US

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