Pregnancy outcomes in a university hospital after legal requirement for single-embryo transfer

Basit Öğe Kaydı
dc.contributor.authorErcan, Cihangir Mutlu
dc.contributor.authorKerimoglu, Ozlem Secilmis
dc.contributor.authorSakinci, Mehmet
dc.contributor.authorKorkmaz, Cem
dc.contributor.authorDuru, Namik Kemal
dc.contributor.authorErgun, Ali
dc.date.accessioned2020-03-26T18:58:25Z
dc.date.available2020-03-26T18:58:25Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: To present our in vitro fertilization outcomes after implementation of the Turkish government policy limiting the number of transferred embryos to one, in women under the age of 35, and two, in women over age 35; and to demonstrate the feasibility of this policy. Study design: We retrospectively reviewed the records of 423 patients who underwent ovarian stimulation, oocyte pick-up, intracytoplasmic sperm injection and embryo transfer due to primary or secondary infertility over a 22-month time interval. Clinical pregnancy was defined as a fetal heartbeat in the seventh gestational week. Embryo transfers were carried out on day 3 or 5. Descriptive statistics are given as the number of subjects and percentages. Results: A total of 353 embryo transfers were performed: 261 (73.9%) were single-embryo transfer (244 (69.1%) elective and 17 (4.8%) non-elective) and 92 (26.1%) were double-embryo transfer. Of the 244 elective single-embryo transfers, 6.6% (n = 16) were performed using frozen-thawed embryos. The average patient age was 29.6 +/- 4.5 years in the single-embryo group and 36.5 +/- 2.4 years in the double-embryo group. The cumulative pregnancy rates per oocyte pick-up were similar in both groups: 41% (n = 107) in the single-embryo group and 43.4% (n = 40) in the double-embryo group (p = 0.678). The cumulative live birth rate of the single-embryo group (32.1%) was not statistically different from the double-embryo group (35.8%) (p = 0.518). The twin pregnancy rate after single-embro transfer was significantly lower than with double-embryo transfer (2.8% (n = 3) vs. 32.5% (n = 13); p < 0.001) and 62.5% of the twin pregnancies occurred in women 35 years or older who underwent double-embryo transfer. No significant difference in the spontaneous abortion rates was recorded between the single- and double-embryo transfer groups (16 (6.1%) vs. 6 (6.5%); p = 0.894). Conclusion: Single-embryo transfer results in a pregnancy rate comparable to double-embryo transfer, with a significantly reduced multiple pregnancy rate. Double-embryo transfer in patients over age 35 should be reconsidered because of the resulting high rate of multiple pregnancy. (C) 2014 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejogrb.2014.01.008en_US
dc.identifier.endpage166en_US
dc.identifier.issn0301-2115en_US
dc.identifier.issn1872-7654en_US
dc.identifier.pmid24485667en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage163en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ejogrb.2014.01.008
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31079
dc.identifier.volume175en_US
dc.identifier.wosWOS:000335432000030en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofEUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectIn vitro fertilizationen_US
dc.subjectSingle embryo transferen_US
dc.subjectMultiple pregnancyen_US
dc.titlePregnancy outcomes in a university hospital after legal requirement for single-embryo transferen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu