Serum galectin-3 level as a marker of thrombogenicity in atrial fibrillation

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dc.contributor.authorKocyigit, Duygu
dc.contributor.authorGurses, Kadri Murat
dc.contributor.authorYalcin, Muhammed Ulvi
dc.contributor.authorCanpinar, Hande
dc.contributor.authorCanpolat, Ugur
dc.contributor.authorEvranos, Banu
dc.contributor.authorYorgun, Hikmet
dc.date.accessioned2020-03-26T19:42:37Z
dc.date.available2020-03-26T19:42:37Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackgroundLeft atrial appendage flow velocity (LAAFV) and presence of spontaneous echo contrast (SEC) have been reported to be predictors of thromboembolism in atrial fibrillation (AF) patients. Galectin-3 is a biomarker reflecting pro-inflammatory status, whose role in AF has recently drawn attention, particularly in persistent AF population. AimIn this study we aimed to investigate the association between serum galectin-3 levels and echocardiographic predictors of thromboembolism in persistent AF patients. MethodsWe included 65 persistent AF patients (55.5010.67years, 46.15% male). Transesophageal echocardiography (TEE) was performed to assess LAAFV and presence of left atrial (LA)/LA appendage (LAA)-located SEC and thrombus prior to direct current cardioversion or catheter ablation for AF. ResultsMedian galectin-3 level was 0.63ng/mL. Serum galectin-3 levels were significantly correlated with LAAFV (r=-.440, P<.001). Serum galectin-3 levels were associated with presence of SEC (P<.001), and LA thrombus (P=.008). Receiver operating characteristic analysis revealed that a serum galectin-3 greater or equal to the cut-off value of 0.69 predicted presence of SEC with a sensitivity and specificity of 91.00% and 79.00%, respectively (P<.001). ConclusionIn conclusion, in the setting of persistent AF, serum galectin-3 levels are associated with presence of SEC and LAAFV on TEE. Our findings suggest that serum galectin-3 level may have a place in thromboembolism risk stratification in persistent AF patients.en_US
dc.description.sponsorshipHacettepe University Scientific Research Projects Coordination UnitHacettepe University [1993]en_US
dc.description.sponsorshipThis research was supported by Hacettepe University Scientific Research Projects Coordination Unit (project number: 1993).en_US
dc.identifier.doi10.1002/jcla.22120en_US
dc.identifier.issn0887-8013en_US
dc.identifier.issn1098-2825en_US
dc.identifier.issue6en_US
dc.identifier.pmid28295609en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1002/jcla.22120
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35471
dc.identifier.volume31en_US
dc.identifier.wosWOS:000416049100009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF CLINICAL LABORATORY ANALYSISen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectatrial fibrillationen_US
dc.subjectgalectin-3en_US
dc.subjectleft atrial appendage flow velocityen_US
dc.subjecttransesophageal echocardiographyen_US
dc.titleSerum galectin-3 level as a marker of thrombogenicity in atrial fibrillationen_US
dc.typeArticleen_US

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