Relation of glutathione S-transferase genotypes (GSTM1 and GSTT1) to laryngeal squamous cell carcinoma risk

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dc.contributor.authorAcar, Hasan
dc.contributor.authorOzturk, Kayhan
dc.contributor.authorMuslumanoglu, M. Hamza
dc.contributor.authorYildirim, M. Selman
dc.contributor.authorCora, Tulin
dc.contributor.authorCilingir, Oguz
dc.contributor.authorOzer, Bedri
dc.date.accessioned2020-03-26T17:04:11Z
dc.date.available2020-03-26T17:04:11Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe purpose of the present study was to investigate GSTM1 and GSTT1 genotypes by using multiplex polymerase chain reaction (PCR) in patients with laryngeal squamous cell carcinoma (LSCC). The genotypes of 110 patients with LSCC and of 197 healthy subjects as the control group were determined by PCR analysis for GSTM1 and GSTT1 genes. Results showed that frequencies of GSTM1-null, GSTT1-null, and both GSTs-null genotypes were 51.8, 30, and 16.4%, respectively, in the patients with LSCC and 37.6, 15.7, and 5.6% in the control group. There was a significant difference between the genotype distributions of all GSTs in patients and in control groups (P < 0.05). The results support the hypothesis that null genotypes of GSTM1 and GSTT1 can reduce detoxification capacity of GSTs as members of the xenobiotic enzyme system. GSTM1-null, GSTT1-null, and both GSTs-null genotypes were more common in the patients with LSCC than in the control group. Patients with both GSTs-null genotypes had the highest risk for supraglottic LSCC in the early period, even if they were light-to-medium smokers. Investigation and determination of the genetic basis of LSCC may contribute to detection of risk groups and to prevent LSCC in the population. (c) 2006 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.cancergencyto.2005.12.007en_US
dc.identifier.endpage93en_US
dc.identifier.issn0165-4608en_US
dc.identifier.issue2en_US
dc.identifier.pmid16938565en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.cancergencyto.2005.12.007
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20648
dc.identifier.volume169en_US
dc.identifier.wosWOS:000240651600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE INCen_US
dc.relation.ispartofCANCER GENETICS AND CYTOGENETICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleRelation of glutathione S-transferase genotypes (GSTM1 and GSTT1) to laryngeal squamous cell carcinoma risken_US
dc.typeArticleen_US

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