Effects of İnsulin and Sulphonylureas on İnsulin-Like Growth Factor-I Levels in Streptozotocin-İnduced Diabetic Rats

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dc.contributor.authorGüney, Engin
dc.contributor.authorKısakol, Gürcan
dc.contributor.authorÖge, Ayşin
dc.contributor.authorYılmaz, Candeğer
dc.contributor.authorKabalak, Taylan
dc.date.accessioned2020-03-26T16:38:58Z
dc.date.available2020-03-26T16:38:58Z
dc.date.issued2002
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractOBJECTIVE: Diabetes Mellitus is associated with decreased insulin-like growth factor-I (IGF-I) levels and also, poor growth in diabetes is related with low circulating levels of IGF-I. Insulin acts via an increase of IGF-I synthesis on growth. We studied the effects of insulin and sulphonylureas on serum IGF-I levels and aimed to evaluate the restoration of IGF-I in different therapeutic strategies. DESIGN AND SETTING: Thirty male rats were used in the study and diabetes was induced by a single intraperitoneal injection of streptozotocin (35 mg/kg body weight). After confirmation of hyperglycemia, rats were divided into three groups. The first group was treated with insulin, and second group with glimepiride, third group was not treated (control group). IGF-I levels were measured at basal, after streptozotocin and at the end of the treatment period. RESULTS: Serum IGF-I levels were found to decrease from 577.2 ng/ml to 253.0 ng/ml after streptozotocin (p<0.005). After 1 month, IGF-1 levels were found 524.0 ng/ml in insulin group, 449.3 ng/ml in sulphonylurea group, and 313.1 ng/ml in control group. The increase in IGF-I was statistically significant in insulin group (p<0.005), and in sulphonylurea group (p<0.05), but it was not significant in control group (p>0.05). CONCLUSIONS: Serum IGF-I levels decrease in diabetes and insulin treatment restores IGF-I depletion significantly. And although less effective, treatment with glimepiride restores IGF-I levels significantly.en_US
dc.identifier.citationGüney, E., Kısakol, G., Öge, A., Yılmaz, C., Kabalak, T., (2002). Effects of İnsulin and Sulphonylureas on İnsulin-Like Growth Factor-I Levels in Streptozotocin-İnduced Diabetic Rats. Neuroendocrinology Letters, 23(5-6), 437-439.
dc.identifier.endpage439en_US
dc.identifier.issn0172-780Xen_US
dc.identifier.issue5-6en_US
dc.identifier.pmid12500166en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage437en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17938
dc.identifier.volume23en_US
dc.identifier.wosWOS:000180255100012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKısakol, Gürcan
dc.language.isoenen_US
dc.publisherMaghira & Maas Publicationsen_US
dc.relation.ispartofNeuroendocrinology Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectIGF-Ien_US
dc.subjectdiabetesen_US
dc.subjectinsulinen_US
dc.subjectsulphonylureaen_US
dc.titleEffects of İnsulin and Sulphonylureas on İnsulin-Like Growth Factor-I Levels in Streptozotocin-İnduced Diabetic Ratsen_US
dc.typeArticleen_US

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