Addition of sufentanil to bupivacaine in caudal block effect on stress responses in children

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dc.contributor.authorErol, Atilla
dc.contributor.authorTuncer, Sema
dc.contributor.authorTavlan, Aybars
dc.contributor.authorReisli, Ruhiye
dc.contributor.authorAysolmaz, Gokhan
dc.contributor.authorOtelcioglu, Seref
dc.date.accessioned2020-03-26T17:16:58Z
dc.date.available2020-03-26T17:16:58Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: The aim of the present randomized study was to determine the effect of adding sufentanil to bupivacaine, compared with bupivacaine alone in caudal block, on the surgical stress response in children. Methods: The children were premedicated with midazolam 0.5 mg/kg. All children received induction with nitrous oxide and sevoflurane. Anesthesia was maintained with the same volatile agents in the both groups. The children were randomly allocated to two groups. Group I received bupivacaine alone (n = 17) and group II received bupivacaine + sufentanil (n = 16). Caudal block was performed with 0.25% bupivacaine 2 mg/kg (group I) or 0.25% bupivacaine 2 mg/kg with sufentanil 0.5 mu g/kg (group II) after induction of anesthesia. Blood samples were obtained after induction of anesthesia (T-0) to measure baseline concentrations of cortisol, prolactin, glucose and insulin. Additional samples were obtained 30 min after the start of surgery (T-1), and 60 min after the end of surgery (T-2). Results: All of the basal values (T-0) were within the normal ranges of the authors' laboratory for children of this age group and there were no differences between the groups (P > 0.05). In both groups, glucose concentration increased at T-1, compared with T-0 and T-2 (P < 0.05). The glucose concentration was unchanged at T-2 compared with T-0 in both group (P > 0.05). In both groups, prolactin concentration increased at T-1, compared with T-0 and decreased at T-2, compared with T-1 (P < 0.05). Cortisol decreased at T-1 and T-2, compared with T-0 in both groups. (P < 0.05). Insulin concentration remained unchanged at T-0 and T-2, but increased slightly at T-1 in both groups (P > 0.05). There were no significant differences in plasma prolactin, cortisol, glucose and insulin levels between the two groups at T-1 and T-2 (P > 0.05). Conclusion: There is no advantage in adding 0.5 mu g/kg sufentanil to bupivacaine over bupivacaine alone in the caudal block, with regard to the surgical stress response in children.en_US
dc.identifier.doi10.1111/j.1442-200X.2007.02479.xen_US
dc.identifier.endpage932en_US
dc.identifier.issn1328-8067en_US
dc.identifier.issue6en_US
dc.identifier.pmid18045299en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage928en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1442-200X.2007.02479.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21200
dc.identifier.volume49en_US
dc.identifier.wosWOS:000251253100026en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBLACKWELL PUBLISHINGen_US
dc.relation.ispartofPEDIATRICS INTERNATIONALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcaudal blocken_US
dc.subjectcortisolen_US
dc.subjectglucoseen_US
dc.subjectinsulinen_US
dc.subjectprolactinen_US
dc.subjectstress responseen_US
dc.subjectsufentanilen_US
dc.titleAddition of sufentanil to bupivacaine in caudal block effect on stress responses in childrenen_US
dc.typeArticleen_US

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