Evaluation of hepatic metabolic activity in non-alcoholic fatty livers on (18)FDG PET/CT

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dc.contributor.authorDostbil, Z.
dc.contributor.authorVaroglu, E.
dc.contributor.authorSerdengecti, M.
dc.contributor.authorKaya, B.
dc.contributor.authorOnder, H.
dc.contributor.authorSari, O.
dc.date.accessioned2020-03-26T18:41:51Z
dc.date.available2020-03-26T18:41:51Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: The liver has been used as a reference organ for the assessment of abnormal F-18-fluoro-2-deoxy-D-glucose ((18)FDG) in the body. Some researchers found that hepatosteatosis significantly changed the hepatic (18)FDG uptake, while others did not. This study investigated whether the liver's (18)FDG uptake was affected by the diffuse fatty infiltration of the liver. Material and methods: A total of 156 cases were included in this study. Different patient groups were defined according to the liver Hounsfield unit (HU). The HU was calculated from an unenhanced CT, for all patients, and we calculated the mean standardized uptake value (STmean) and maximum standardized uptake value (SUNmax) on an (18)FDG PET scan. For this purpose, we placed regions of interest (ROIs) on the liver image. We statistically compared the SUVmean and SUVmax measured in the fatty liver patients and the control group. Results: The average SUVmean and SUVmax values were calculated as 2.58 +/- 0.66 and 3.94 +/- 1, respectively, in the patient group and 2.54 +/- 0.57 and 3.7 +/- 0.88, respectively, in the control group. We found the average SUVmean and SUVmax values in the fatty liver group and its subsets were not significantly different from the values in the control group (p > 0.05). We also did not find any statistically significant correlation between average liver density (HU) and the average SUV values (p > 0.05). Conclusion: Fatty infiltration may not have a significant effect on the liver's (18)FDG uptake. Thus, the liver may be used as a reference or comparator on (18)FDG PET scans in patients with fatty liver disease. (C) 2012 Elsevier Espana, S.L. and SEMNIM. All rights reserved.en_US
dc.identifier.doi10.1016/j.remn.2012.04.006en_US
dc.identifier.endpage161en_US
dc.identifier.issn2253-654Xen_US
dc.identifier.issue3en_US
dc.identifier.pmid23177332en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage156en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.remn.2012.04.006
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29486
dc.identifier.volume32en_US
dc.identifier.wosWOS:000319026700004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER DOYMA SLen_US
dc.relation.ispartofREVISTA ESPANOLA DE MEDICINA NUCLEAR E IMAGEN MOLECULARen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectFatty liveren_US
dc.subject(18)FDGen_US
dc.subjectPET CTen_US
dc.subjectStandardized uptake valueen_US
dc.titleEvaluation of hepatic metabolic activity in non-alcoholic fatty livers on (18)FDG PET/CTen_US
dc.typeArticleen_US

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