Investigation of the Association of the Second-to-Fourth Digit Ratio with Skin Sebum Levels in Females with Acne Vulgaris

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dc.contributor.authorBilgic, Ozlem
dc.contributor.authorAltinyazar, Cevdet
dc.contributor.authorHira, Huseyin
dc.contributor.authorDogdu, Murat
dc.date.accessioned2020-03-26T19:06:12Z
dc.date.available2020-03-26T19:06:12Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground A relationship between acne vulgaris (AV) and the masculinized (lower) second-to-fourth digit (2D:4D) ratio in females was demonstrated in our previous study. Development of the digits and the sebaceous glands both occur during the same gestational period; therefore, the association between the 2D:4D ratios and AV may result from the effects of the prenatal endocrine environment on the sebaceous glands. Objective The aim of this study was to evaluate the relationship between the 2D:4D ratio and sebum levels in the skin of females with AV. Methods In total, 215 female AV patients and 92 healthy controls, aged 18-35 years, were enrolled in this study. Finger-length measurements were made using a digital Vernier caliper, and the sebum levels of five facial areas were measured using a Sebumeter SM 815. Acne severity was assessed using the International Consensus Conference on Acne Classification System. Results The 2D:4D ratios of the AV patients were significantly lower than those of the controls, for both hands. The mean sebum levels in the T-zone, U-zone and whole face were significantly higher for AV patients compared with controls. The 2D:4D ratio in the left hand showed significant negative correlations with the sebum levels in the U-zone; however, no association was found between the 2D:4D ratios and sebum levels in the T-zone and whole face. While acne severity was positively correlated with skin sebum levels, no correlation between acne severity and 2D:4D ratios was observed. Conclusion This study provides preliminary evidence regarding the association between lower 2D:4D ratios and higher rates of sebum secretion in the U-zone for females with AV. The 2D:4D ratio might be a predictor of sebum levels, as well as acne development, in females.en_US
dc.description.sponsorshipTurkish Scientific and Technical Research Council (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113S671]en_US
dc.description.sponsorshipThis study was supported by the Turkish Scientific and Technical Research Council (TUBITAK, Project No. 113S671).en_US
dc.identifier.doi10.1007/s40257-015-0147-3en_US
dc.identifier.endpage564en_US
dc.identifier.issn1175-0561en_US
dc.identifier.issn1179-1888en_US
dc.identifier.issue6en_US
dc.identifier.pmid26242229en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage559en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s40257-015-0147-3
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32267
dc.identifier.volume16en_US
dc.identifier.wosWOS:000365509800009en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherADIS INT LTDen_US
dc.relation.ispartofAMERICAN JOURNAL OF CLINICAL DERMATOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleInvestigation of the Association of the Second-to-Fourth Digit Ratio with Skin Sebum Levels in Females with Acne Vulgarisen_US
dc.typeArticleen_US

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