Omental Transposition Decreases Ischemic Brain Damage Examined in a New Ischemia Model

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dc.contributor.authorVatansev, Celalettin
dc.contributor.authorÜstün, M. E.
dc.contributor.authorÖğün, C. O.
dc.contributor.authorTaştekin, G.
dc.contributor.authorKarabacakoğlu, A.
dc.contributor.authorYılmaz, H.
dc.date.accessioned2020-03-26T16:45:55Z
dc.date.available2020-03-26T16:45:55Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose:The aim of this study was to determine whether omental transposition at the time of focal cerebral ischemia can decrease ischemic brain damage produced in dogs, in a new ischemia model, which had been described by us. Methods: In group 1 (n = 5), the left internal carotid artery and arterial circle of the brain (posterior communicating artery in humans) were occluded permanently. In group 2 (n = 5), additionally to this ischemia model, omental transposition was performed simultaneously. In the postoperative early period (first 24 h), single photon emission computed tomography (SPECT) and in the late period (72-96 h) SPECT and magnetic resonance imaging (MRI) of the brain were performed. Mann-Whitney U, paired t and Wilcoxon signed rank tests were used for statistical analyses, and p < 0.05 was considered significant. Results: The dogs had a neurological score (NS) of 3.6 +/- 0.5 and 3.4 +/- 0.5 in groups 1 and 2, respectively, in the early period (p > 0.05). In the late period, the dogs had an NS of 4.4 +/- 0.5 and 5.6 +/- 0.5 in groups 1 and 2, respectively (p < 0.05). The NS of each group differed significantly between the early and late period (p < 0.05). Early SPECT imaging showed 50 7.0% and 52 +/- 8.4% hypoperfusion corresponding to the left middle cerebral artery territory in groups 1 and 2, respectively (p > 0.05). In the late period, the degree of hypoperfusion decreased to 34 +/- 5.5% and 12 +/- 4.8% in groups 1 and 2, respectively (p < 0.05). The degree of hypoperfusion in both groups changed significantly between the early and late period (p < 0.05). In T-1- and T-2-weighted MRI images, the volume of the lesion in group 1 was significantly greater than in group 2 (p < 0.001). Conclusion: In our new ischemia model, simultaneous omental transposition is helpful in reversing the neurologic deficit and cerebral ischemic damage.en_US
dc.identifier.citationVatansev, C., Üstün, M. E., Öğün, C. O., Taştekin, G., Karabacakoğlu, A., Yılmaz, H., (2003). Omental Transposition Decreases Ischemic Brain Damage Examined in a New Ischemia Model. European Surgical Research, (35), 388-394. Doi: 10.1159/000070612
dc.identifier.doi10.1159/000070612en_US
dc.identifier.endpage394en_US
dc.identifier.issn0014-312Xen_US
dc.identifier.pmid12802102en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage388en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000070612
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18518
dc.identifier.volume35en_US
dc.identifier.wosWOS:000183887300010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorVatansev, Celalettin
dc.institutionauthorÜstün, M. E.
dc.institutionauthorÖğün, C. O.
dc.institutionauthorTaştekin, G.
dc.institutionauthorKarabacakoğlu, A.
dc.institutionauthorYılmaz, H.
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofEuropean Surgical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCerebral İschemiaen_US
dc.subjectOmental Transpositionen_US
dc.subjectSingle Photon Emission Computed Tomographyen_US
dc.subjectMagnetic Resonance İmagingen_US
dc.subjectExperimental Modelen_US
dc.titleOmental Transposition Decreases Ischemic Brain Damage Examined in a New Ischemia Modelen_US
dc.typeArticleen_US

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