Evaluation of the levels of oxidative stress factors and ischemia modified albumin in the cord blood of smoker and non-smoker pregnant women

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dc.contributor.authorSahinli, Ayla Songul
dc.contributor.authorMarakoglu, Kamile
dc.contributor.authorKiyici, Aysel
dc.date.accessioned2020-03-26T18:25:42Z
dc.date.available2020-03-26T18:25:42Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: The aim of this cross-sectional study was to determine the oxidant and antioxidant status and a novel ischemia marker - ischemia modified albumin - in the cord blood of smoker and non-smoker pregnants. Methods: This study was performed on 30 smoker and 60 non-smoker pregnant women. Malondialdehyde (MDA), vitamin A and E, total antioxidant capacity (TAC) and ischemia modified albumin (IMA) levels and superoxide dismutase activities (SOD) were determined in the cord blood of the contributors. Results: In the cord blood of the smoker women compared to the non-smokers; MDA (mu mol/L) levels increased (5.17 +/- 0.25, 3.60 +/- 0.06, p = 0.000), IMA (ABSU) levels increased (0.913 +/- 0.02, 0.830 +/- 0.01, p = 0.050), SOD (U/ml) activities decreased (8.22 +/- 0.14, 8.63 +/- 0.14, p = 0.045), Vit A (mu g/L) (339.06 +/- 17.52, 454.91 +/- 16.56, p = 0.000) and Vit E (mg/L) levels decreased (2.8 +/- 0.15, 7.58 +/- 0.38, p = 0.000) and TAC (Mm Trolox) levels decreased (3.25 +/- 0.15, 4.08 +/- 0.09, p = 0.000), and these differences were statistically significant. We found moderate and strong positive correlations between smoking status and IMA (r = 0.325, p = 0.002) and smoking status and MDA levels (r = 0.636, p = 0.000). Smoking status presented weak, moderate and strong negative correlations with SOD activities, TAC, Vit A and Vit E levels, respectively (r = -0.237, p = 0.024), (r = -0.420, p = 0.000), (r = -0.443, p=0.000), (r = -0.795, p = 0.000). Conclusion: It was determined that smoking cigarette during gestation disturbed the balance between the oxidant and antioxidant system and caused oxidative stress. Increased IMA levels in cord blood of smoker pregnants suggests that smoking during pregnancy causes fetal ischemia.en_US
dc.description.sponsorshipSelcuk University Scientific Research and Projects CommitteeSelcuk University [08102012]en_US
dc.description.sponsorshipSelcuk University Scientific Research and Projects Committee funded this study (Project Number: 08102012).en_US
dc.identifier.doi10.3109/14767058.2011.622001en_US
dc.identifier.endpage1068en_US
dc.identifier.issn1476-7058en_US
dc.identifier.issn1476-4954en_US
dc.identifier.issue7en_US
dc.identifier.pmid21916812en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1064en_US
dc.identifier.urihttps://dx.doi.org/10.3109/14767058.2011.622001
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28045
dc.identifier.volume25en_US
dc.identifier.wosWOS:000305704000039en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofJOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCigaretteen_US
dc.subjectgestationen_US
dc.subjectischemia modified albuminen_US
dc.subjectoxidative stressen_US
dc.titleEvaluation of the levels of oxidative stress factors and ischemia modified albumin in the cord blood of smoker and non-smoker pregnant womenen_US
dc.typeArticleen_US

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