Nicotinamide N-methyltransferase expression and its association with phospho-Akt, p53 expression, and survival in high-grade endometrial cancer

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dc.contributor.authorAkar, Serra
dc.contributor.authorHarmankaya, Ismail
dc.contributor.authorUgras, Serdar
dc.contributor.authorCelik, Cetin
dc.date.accessioned2020-03-26T20:15:28Z
dc.date.available2020-03-26T20:15:28Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground/aim: Nicotinamide N-methyltransferase (NNMT) is an enzyme that is overexpressed in malignancies. NNMT expression has not been previously studied in endometrial cancer (EC). Increased phospho-Akt (pAkt) levels in response to NNMT overexpression have been reported in in vitro studies of different cancer types. We assayed NNMT expression in primary and metastatic high-grade EC and investigated the relationship of NNMT with p53, pAkt, and survival. Materials and methods: NNMT, pAkt, and p53 expressions were assayed in 100 tissue samples of benign endometria, primary EC, and metastatic EC by immunohistochemistry. Results: The NNMT immunoreactivity score was significantly higher in primary high-grade EC than benign endometrial tissue (P = 0.001). NNMT expression in metastatic tissue was significantly higher than in primary cancer (P < 0.001). Metastatic stromal NNMT expression was significantly higher than that of the adjacent tumor and stroma adjacent to the primary tumor. p53 expression in the primary tumor showed a significant positive correlation with omental NNMT and pAkt expression. NNMT expression was also correlated with pAkt expression in metastatic tissue. NNMT overexpression in metastatic tissue was associated with decreased survival (P = 0.039). Conclusion: This study suggests that NNMT may promote cancer progression and that NNMT overexpression is associated with aberrant p53 expression, pAkt, and poor survival. NNMT's role in cancer progression could make it a target of EC therapy.en_US
dc.description.sponsorshipSelcuk University Scientific Research EndorsementSelcuk University [18401135]en_US
dc.description.sponsorshipThis study was funded by the Selcuk University Scientific Research Endorsement (#18401135).en_US
dc.identifier.citationAkar, S., Harmankaya, İ., Ugras, S., Çelik, Ç. (2019). Nicotinamide N-Methyltransferase Expression And İts Association With Phospho-Akt, P53 Expression, And Survival İn High-Grade Endometrial Cancer. Turkish Journal Of Medical Sciences, 49,(5), 1547-1554.
dc.identifier.doi10.3906/sag-1907-166en_US
dc.identifier.endpage1554en_US
dc.identifier.issn1300-0144en_US
dc.identifier.issn1303-6165en_US
dc.identifier.issue5en_US
dc.identifier.pmid31652035en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1547en_US
dc.identifier.urihttps://dx.doi.org/10.3906/sag-1907-166
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38037
dc.identifier.volume49en_US
dc.identifier.wosWOS:000504050500042en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorHarmankaya, Ismail
dc.institutionauthorUgras, Serdar
dc.language.isoenen_US
dc.publisherTUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEYen_US
dc.relation.ispartofTURKISH JOURNAL OF MEDICAL SCIENCESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectNicotinamide N-methyltransferaseen_US
dc.subjecttype II endometrial canceren_US
dc.subjectAkten_US
dc.subjectp53en_US
dc.subjectdisease-specific survivalen_US
dc.titleNicotinamide N-methyltransferase expression and its association with phospho-Akt, p53 expression, and survival in high-grade endometrial canceren_US
dc.typeArticleen_US

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