Comparison of the Diagnostic Accuracy of Five Different Stool Antigen Tests for the Diagnosis of Helicobacter pylori Infection

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dc.contributor.authorKorkmaz, Huseyin
dc.contributor.authorKesli, Recep
dc.contributor.authorKarabagli, Pinar
dc.contributor.authorTerzi, Yuksel
dc.date.accessioned2020-03-26T18:41:20Z
dc.date.available2020-03-26T18:41:20Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Several noninvasive diagnostic tests based on the detection of Helicobacter pylori stool antigen (HpSA) have been developed. The aim of the study was to compare the diagnostic accuracy of 5 HpSA tests-2 monoclonal enzyme immunoassay tests (EIAs: the Premier Platinum HpSA Plus test and Helicobacter pylori Antigen (Hp Ag) test) and 3 rapid immunochromatographic assay (ICA) tests (the ImmunoCard STAT! HpSA test, one step HpSA test, and H. pylori fecal antigen test)-for diagnosing H. pylori infection in adult patients with dyspeptic symptoms before eradication therapy. Materials and Methods: A total of 198 patients with dyspeptic symptoms were included in the study. A gastric biopsy was collected for histopathology and rapid urease testing. Stool specimens for HpSA testing were also collected. Patients were considered H. pylori positive if two invasive tests (histological and rapid urease tests) were positive. Results: The sensitivity and specificity were 92.2% and 94.4%, respectively, for the Premier Platinum HpSA Plus test; 48.9% and 88.9%, respectively, for the HP Ag test; 86.7% and 88.9, respectively, for the One Step HpSA test; 68.9% and 92.6%, respectively, for the ImmunoCard STAT! HpSA test; and 78.9% and 87%, respectively, for the H. Pylori fecal antigen test. Conclusions: The Premier Platinum HpSA Plus EIA test was determined to be the most accurate stool test for diagnosing H. pylori infections in adult dyspeptic patients. The currently available ICA-based tests are fast and easy to use but provide less reliable results.en_US
dc.identifier.doi10.1111/hel.12053en_US
dc.identifier.endpage391en_US
dc.identifier.issn1083-4389en_US
dc.identifier.issn1523-5378en_US
dc.identifier.issue5en_US
dc.identifier.pmid23551920en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage384en_US
dc.identifier.urihttps://dx.doi.org/10.1111/hel.12053
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29318
dc.identifier.volume18en_US
dc.identifier.wosWOS:000322923000009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofHELICOBACTERen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectHelicobacter pylori diagnosisen_US
dc.subjectstool antigen testen_US
dc.subjectimmunoassayen_US
dc.subjectsensitivityen_US
dc.subjectspecificityen_US
dc.titleComparison of the Diagnostic Accuracy of Five Different Stool Antigen Tests for the Diagnosis of Helicobacter pylori Infectionen_US
dc.typeArticleen_US

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