A Randomized Comparison of Acitretin-narrow-band TL-01 Phototherapy and Acitretin-Psoralen plus Ultraviolet A for Psoriasis

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dc.contributor.authorOezemir, Mustafa
dc.contributor.authorEngin, Burhan
dc.contributor.authorBaysal, Ibrahim
dc.contributor.authorMevlitoglu, Inci
dc.date.accessioned2020-03-26T17:26:21Z
dc.date.available2020-03-26T17:26:21Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe combination of retinoids with phototherapy enhances the efficacy of phototherapy and reduces the cumulative ultraviolet dose and duration of the therapy needed to treat chronic plaque psoriasis. Although TL-01 phototherapy has been used widely, there are few data about the effectiveness of the combination of acitretin with TL-01 in treatment of the disease. The aim of this study was to compare acitretin-narrow-band TL-01 phototherapy with acitretin-psoralen plus ultraviolet A (acitretin-PUVA) in psoriasis. We studied 60 patients with moderate to severe plaque psoriasis who were randomly allocated to three times weekly treatment acitretin-narrow-band TL-01 or acitretin-PUVA. The efficacy of treatments was assessed using the Psoriasis Area and Severity Index by a blinded observer. Clearance of psoriasis was achieved in 56.6% of patients treated with acitretin-narrow-band TL-01 and in 63.3% of those treated with acitretin-PUVA. All of these patients remained clear of psoriasis 3 months after finishing the treatments. Mucocutaneous side-effects, such as dry lips and mouth, were the most common complaints in both groups. In conclusion, acitretin-narrow-band TL-01 is an effective and well-tolerated treatment for moderate to severe plaque psoriasis, with a therapeutic effect equal to that of acitretin-PUVA.en_US
dc.identifier.doi10.2340/00015555-0529en_US
dc.identifier.endpage593en_US
dc.identifier.issn0001-5555en_US
dc.identifier.issue6en_US
dc.identifier.pmid19002344en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage589en_US
dc.identifier.urihttps://dx.doi.org/10.2340/00015555-0529
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22173
dc.identifier.volume88en_US
dc.identifier.wosWOS:000261098300008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherACTA DERMATO-VENEREOLOGICAen_US
dc.relation.ispartofACTA DERMATO-VENEREOLOGICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectphototherapyen_US
dc.subjectpsoriasisen_US
dc.subjectretinoiden_US
dc.subjectre-TL-01en_US
dc.subjectre-PUVAen_US
dc.titleA Randomized Comparison of Acitretin-narrow-band TL-01 Phototherapy and Acitretin-Psoralen plus Ultraviolet A for Psoriasisen_US
dc.typeArticleen_US

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