Clinical and epidemiological features of Turkish children with 2009 pandemic influenza A (H1N1) infection: Experience from multiple tertiary paediatric centres in Turkey

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dc.contributor.authorCiftci, Ergin
dc.contributor.authorTuygun, Nilden
dc.contributor.authorOzdemir, Halil
dc.contributor.authorTezer, Hasan
dc.contributor.authorSensoy, Gulnar
dc.contributor.authorDevrim, Ilker
dc.contributor.authorDalgic, Nazan
dc.date.accessioned2020-03-26T18:13:56Z
dc.date.available2020-03-26T18:13:56Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: In April 2009 a novel strain of human influenza A, identified as H1N1 virus, rapidly spread worldwide, and in early June 2009 the World Health Organization raised the pandemic alert level to phase 6. Herein we present the largest series of children who were hospitalized due to pandemic H1N1 infection in Turkey. Methods: We conducted a retrospective multicentre analysis of case records involving children hospitalized with influenza-like illness, in whom 2009 H1N1 influenza was diagnosed by reverse-transcriptase polymerase chain reaction assay, at 17 different tertiary hospitals. Results: A total of 821 children with 2009 pandemic H1N1 were hospitalized. The majority of admitted children (56.9%) were younger than 5 y of age. Three hundred and seventy-six children (45.8%) had 1 or more pre-existing conditions. Respiratory complications including wheezing, pneumonia, pneumothorax, pneumomediastinum, and hypoxemia were seen in 272 (33.2%) children. Ninety of the patients (11.0%) were admitted or transferred to the paediatric intensive care units (PICU) and 52 (6.3%) received mechanical ventilation. Thirty-five children (4.3%) died. The mortality rate did not differ between age groups. Of the patients who died, 25.7% were healthy before the H1N1 virus infection. However, the death rate was significantly higher in patients with malignancy, chronic neurological disease, immunosuppressive therapy, at least 1 pre-existing condition, and respiratory complications. The most common causes of mortality were pneumonia and sepsis. Conclusions: In Turkey, 2009 H1N1 infection caused high mortality and PICU admission due to severe respiratory illness and complications, especially in children with an underlying condition.en_US
dc.identifier.doi10.3109/00365548.2011.598872en_US
dc.identifier.endpage929en_US
dc.identifier.issn0036-5548en_US
dc.identifier.issue11.12.2020en_US
dc.identifier.pmid21859378en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage923en_US
dc.identifier.urihttps://dx.doi.org/10.3109/00365548.2011.598872
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26232
dc.identifier.volume43en_US
dc.identifier.wosWOS:000296641500012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherINFORMA HEALTHCAREen_US
dc.relation.ispartofSCANDINAVIAN JOURNAL OF INFECTIOUS DISEASESen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectChildrenen_US
dc.subjectinfluenza Aen_US
dc.subjectH1N1en_US
dc.subjectmortalityen_US
dc.titleClinical and epidemiological features of Turkish children with 2009 pandemic influenza A (H1N1) infection: Experience from multiple tertiary paediatric centres in Turkeyen_US
dc.typeArticleen_US

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