Drug Induced Lupus Erythematosus Due to Capecitabine and Bevacizumab Treatment Presenting with Prolonged Thrombocytopenia
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Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
DE GRUYTER OPEN LTD
Access Rights
info:eu-repo/semantics/openAccess
Abstract
yDrug induced lupus erythematosus (DILE) is a syndrome that is formed by lupus-like symptoms and laboratory characteristics. Capecitabine is an orally administered tumor-selective fluoropyrimidine that acts as a prodrug of 5-Fluorouracil and bevacizumab is an antivascular endothelial growth factor (anti-VEGF) antibody, both are used for the treatment of patients with colorectal cancer. Herein we report the first case of DILE in a 68-year-old woman who presented with arthralgia, myalgia and prolonged thrombocytopenia after receiving capecitabine and bevacizumab combination treatment as palliative treatment for metastatic colon cancer. Platelet levels were increased and joint complaints disappeared in the first week of hydroxychloroquine and methylprednisolone treatment after chemotherapy had been discontinued. In conclusion, physicians should be alert to the possibility of DILE in patients presenting with thrombocytopenia under a capecitabine and bevacizumab chemotherapy regimen.
Description
Keywords
capecitabine, drug induced lupus erythematosus, thrombocytopenia
Journal or Series
ROMANIAN JOURNAL OF INTERNAL MEDICINE
WoS Q Value
N/A
Scopus Q Value
Volume
53
Issue
3
