Drug Induced Lupus Erythematosus Due to Capecitabine and Bevacizumab Treatment Presenting with Prolonged Thrombocytopenia

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dc.contributor.authorÖzaslan, Ersin
dc.contributor.authorEroğlu, Eray
dc.contributor.authorGök, Kevser
dc.contributor.authorŞenel, Soner
dc.contributor.authorBaldane, Süleyman
dc.contributor.authorAkyol, Lütfi
dc.contributor.authorÖzkan, Metin
dc.date.accessioned2020-03-26T19:01:58Z
dc.date.available2020-03-26T19:01:58Z
dc.date.issued2015
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractyDrug induced lupus erythematosus (DILE) is a syndrome that is formed by lupus-like symptoms and laboratory characteristics. Capecitabine is an orally administered tumor-selective fluoropyrimidine that acts as a prodrug of 5-Fluorouracil and bevacizumab is an antivascular endothelial growth factor (anti-VEGF) antibody, both are used for the treatment of patients with colorectal cancer. Herein we report the first case of DILE in a 68-year-old woman who presented with arthralgia, myalgia and prolonged thrombocytopenia after receiving capecitabine and bevacizumab combination treatment as palliative treatment for metastatic colon cancer. Platelet levels were increased and joint complaints disappeared in the first week of hydroxychloroquine and methylprednisolone treatment after chemotherapy had been discontinued. In conclusion, physicians should be alert to the possibility of DILE in patients presenting with thrombocytopenia under a capecitabine and bevacizumab chemotherapy regimen.en_US
dc.identifier.doi10.1515/rjim-2015-0037en_US
dc.identifier.endpage285en_US
dc.identifier.issn1582-3296en_US
dc.identifier.issn2501-062Xen_US
dc.identifier.issue3en_US
dc.identifier.pmid26710505en_US
dc.identifier.startpage282en_US
dc.identifier.urihttps://dx.doi.org/10.1515/rjim-2015-0037
dc.identifier.urihttps://hdl.handle.net/20.500.12395/32023
dc.identifier.volume53en_US
dc.identifier.wosWOS:000217665500012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDE GRUYTER OPEN LTDen_US
dc.relation.ispartofROMANIAN JOURNAL OF INTERNAL MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcapecitabineen_US
dc.subjectdrug induced lupus erythematosusen_US
dc.subjectthrombocytopeniaen_US
dc.titleDrug Induced Lupus Erythematosus Due to Capecitabine and Bevacizumab Treatment Presenting with Prolonged Thrombocytopeniaen_US
dc.typeArticleen_US

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