Investigation of the Effects of Melatonin and Steroid (st) in Preventing of Testicular Atrophy After Surgical Management Performed with Fowler-Stephens Procedure of Intraabdominal Testis in Late Period
Küçük Resim Yok
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: Identifying of the effects of melatonin (M) and steroid St) which prevents testicular atrophy at the surgical treatment of intraabdominal testes with the procedure of Fowler-Stephens (FS). Material and Method: The vessels of right funiculus spermaticus (FSP) of rats, except in Sham (S) group, were ligated and cut under the kidney (KD) with intraabdominal procedure. The vessels of FSP were ligated and cut under the KD in Control (FS) group. St and M groups were injected intramuscularly with steroid at 2 mg/kg; intraperitoneally with M 17 ?g/kg 30 minutes before cutting the vessels of FSP under the KD. St and M injections were continued for 7 days in seven-dose St and seven-dose M groups respectively. All tissues were examined for the levels of MDA (malondialdehyde) and JS (Johnsen's score) after weighing them. The levels of follicule stimulam hormon (FSH), luteotrope hormon (LH), and free testosteron (FT) in blood were measured. Results: The values of FSH were significantly higher in S group compared with One-dose M group. The levels of MDA were identified to be increased in One-dose St group compared with Seven-dose St group, to be decreased in One-dose St group compared with One-dose M group and in Seven-dose St group compared with Seven-dose M group. The values of JS in S group were higher compared with FS group. Conclusions: One-dose and seven-dose St and M have positive effect regarding JS. MDA was identified to be decreased with seven-dose steroid. As a result M and St seem to be effective in preventing testicular atrophy and injury occurred due to FS.
Açıklama
Anahtar Kelimeler
Fowler-Stephens, Intraabdominal testes, Johnsen's score
Kaynak
Çocuk Cerrahisi Dergisi
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
22
Sayı
1
Künye
Yurtçu, M., Abasıyanık, A., Gökçe, R., Avınduk, M. C., Özdamar, M. Y. (2008). İntraandominal testislerin fowler-stephens yöntemi ile yapılan cerrahi tedavisinden sonra gelişen testis atrofisini önlemede melatonin ve steroidin uzun dönem etkilerinin araştırılması. Çocuk Cerrahisi Dergisi, 22, (1), 33 - 38.
