Distinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota

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dc.contributor.authorIraola, Gregorio
dc.contributor.authorForster, Samuel C.
dc.contributor.authorKumar, Nitin
dc.contributor.authorLehours, Philippe
dc.contributor.authorBekal, Sadjia
dc.contributor.authorGarcia-Pena, Francisco J.
dc.contributor.authorPaolicchi, Fernando
dc.date.accessioned2020-03-26T19:34:55Z
dc.date.available2020-03-26T19:34:55Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractCampylobacter fetus is a venereal pathogen of cattle and sheep, and an opportunistic human pathogen. It is often assumed that C. fetus infection occurs in humans as a zoonosis through food chain transmission. Here we show that mammalian C. fetus consists of distinct evolutionary lineages, primarily associated with either human or bovine hosts. We use whole-genome phylogenetics on 182 strains from 17 countries to provide evidence that C. fetus may have originated in humans around 10,500 years ago and may have "jumped" into cattle during the livestock domestication period. We detect C. fetus genomes in 8% of healthy human fecal metagenomes, where the human-associated lineages are the dominant type (78%). Thus, our work suggests that C. fetus is an unappreciated human intestinal pathobiont likely spread by human to human transmission. This genome-based evolutionary framework will facilitate C. fetus epidemiology research and the development of improved molecular diagnostics and prevention schemes for this neglected pathogen.en_US
dc.description.sponsorshipComision Sectorial de Investigacion Cientifica (CSIC, Uruguay)Consejo Superior de Investigaciones Cientificas (CSIC); Agencia Nacional de Investigacion e Innovacion (ANII, Uruguay) [FSSA_X_2014_1_105252]; Australian National Health and Medical Research CouncilNational Health and Medical Research Council of Australia [1091097]; Victorian Government; Fondo de Convergencia Estructural del Mercosur (FOCEM) [COF 03/11]; Wellcome TrustWellcome Trust [098051]; Medical Research Council UKMedical Research Council UK (MRC) [PF451]en_US
dc.description.sponsorshipWe acknowledge the Pathogen Informatics and Sequencing groups at the Wellcome Trust Sanger Institute for technical support. We also thank to Mark Stares and Hilary Browne at the Host-Microbiota Interactions Laboratory, Wellcome Trust Sanger Institute, for their technical support. G.I. is supported by the Comision Sectorial de Investigacion Cientifica (CSIC, Uruguay) and by the Agencia Nacional de Investigacion e Innovacion (ANII, Uruguay) grant FSSA_X_2014_1_105252. S.C.F. is supported by the Australian National Health and Medical Research Council (1091097) and the Victorian Government's Operational Infrastructure Support Program. This work received financial support from Fondo de Convergencia Estructural del Mercosur (FOCEM) grant COF 03/11, the Wellcome Trust grant number 098051 and the Medical Research Council UK grant number PF451.en_US
dc.identifier.doi10.1038/s41467-017-01449-9en_US
dc.identifier.issn2041-1723en_US
dc.identifier.pmid29118316en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1038/s41467-017-01449-9
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34975
dc.identifier.volume8en_US
dc.identifier.wosWOS:000414662500008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNATURE PUBLISHING GROUPen_US
dc.relation.ispartofNATURE COMMUNICATIONSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleDistinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiotaen_US
dc.typeArticleen_US

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