Serum leptin, adiponectin, resistin and ghrelin levels in psoriatic patients treated with cyclosporin

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dc.contributor.authorOzdemir, Mustafa
dc.contributor.authorYuksel, Mavise
dc.contributor.authorGokbel, Hakki
dc.contributor.authorOkudan, Nilsel
dc.contributor.authorMevlitoglu, Inci
dc.date.accessioned2020-03-26T18:31:18Z
dc.date.available2020-03-26T18:31:18Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractCyclosporin has various effects on adipose tissue and glucose metabolism. This situation may lead to changes in serum levels of adipocyte-derived cytokines which have influence on the pathogenesis of psoriasis. The aim of this study was to evaluate the effect of cyclosporin treatment on some adipocyte-derived cytokines in psoriatic patients. This casecontrol study was performed between June 2009 and March 2010, at the Department of Dermatology of Meram School of Medicine. Serum leptin, adiponectin, resistin and ghrelin levels were assessed in 26 patients with psoriasis before and after cyclosporin treatment and body mass index-matched 26 healthy control subjects. The adipokines levels were compared between the groups. Serum leptin, ghrelin, resistin and adiponectin levels in patients with psoriasis before the treatment were higher than those of the control group but the differences were not statistically significant. A positive correlation between serum leptin and family history of psoriasis was detected (r = 0.398, P = 0.044). A strong negative correlation between the Psoriasis Area and Severity Index and serum ghrelin levels was seen (r = -0.52, P = 0.001) and there was a strong positive correlation between the Nail Psoriasis Severity Index and serum resistin levels (r = 0.62, P = 0.001). Following the treatment, a significant increase was seen in the serum level of adiponectin (P = 0.02) and resistin (P = 0.003). The correlations between the adipokines and the disease parameters before the treatment were lost after the treatment. Our results suggest that levels of some adipocyte-derived cytokines in psoriatic patients are affected by cyclosporin treatment.en_US
dc.description.sponsorshipUniversity of SelcukSelcuk University [09102018]en_US
dc.description.sponsorshipThis study was supported by the Research Fund of the University of Selcuk (project no.: 09102018)en_US
dc.identifier.doi10.1111/j.1346-8138.2011.01497.xen_US
dc.identifier.endpage448en_US
dc.identifier.issn0385-2407en_US
dc.identifier.issue5en_US
dc.identifier.pmid22300284en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage443en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1346-8138.2011.01497.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28401
dc.identifier.volume39en_US
dc.identifier.wosWOS:000302722100005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.relation.ispartofJOURNAL OF DERMATOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectadiponectinen_US
dc.subjectleptinen_US
dc.subjectpsoriasisen_US
dc.subjectresistin and ghrelinen_US
dc.titleSerum leptin, adiponectin, resistin and ghrelin levels in psoriatic patients treated with cyclosporinen_US
dc.typeArticleen_US

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