Correliation Between Osteopontin Protein Expression and Histological Grade of Astrocytomas

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dc.contributor.authorToy, H.
dc.contributor.authorYavas, O.
dc.contributor.authorEren, O.
dc.contributor.authorGenc, M.
dc.contributor.authorYavas, C.
dc.date.accessioned2020-03-26T17:38:09Z
dc.date.available2020-03-26T17:38:09Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractOsteopontin is a ligand for the integrin proteins, which are cell surface receptors that mediate the physical and functional interactions between a cell and the extracellular matrix. The expression of osteopontin is reportedly increased in a number of transformed cell lines and tumor tissues. Furthermore, increased expression of osteopontin results in some infiltrative features of tumors. The aim of the study is to demonstrate that expression of osteopontin in human astrocytomas correlates with histological tumor grade. The expression of osteopontin in human astrocytomas was determined with immunohistochemistry. Median osteopontin expression levels were 1%, 7.5%, 60%, and 50% in grade I, II, III, and IV tumors, respectively. Osteopontin staining was significantly higher in high grade (grade III-IV) than low grade (grade I-II) tumors. These findings indicate that osteopontin immunoreactivity in human astrocytomas may correlate with the grade of a tumor.en_US
dc.identifier.doi10.1007/s12253-008-9130-0en_US
dc.identifier.endpage207en_US
dc.identifier.issn1219-4956en_US
dc.identifier.issn1532-2807en_US
dc.identifier.issue2en_US
dc.identifier.pmid19048398en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage203en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s12253-008-9130-0
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23389
dc.identifier.volume15en_US
dc.identifier.wosWOS:000266091600007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofPATHOLOGY & ONCOLOGY RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectOsteopontinen_US
dc.subjectBrain tumoren_US
dc.subjectGradeen_US
dc.subjectAstrocytomasen_US
dc.titleCorreliation Between Osteopontin Protein Expression and Histological Grade of Astrocytomasen_US
dc.typeArticleen_US

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