An aggressive parameningeal rhabdomyosarcoma with multiple spinal cord metastases: a case report and review of the literature

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dc.contributor.authorYavas, Guler
dc.contributor.authorKarabagli, Pinar
dc.contributor.authorPaksoy, Yahya
dc.contributor.authorYavas, Cagdas
dc.contributor.authorKarabagli, Hakan
dc.contributor.authorKoksal, Yavuz
dc.date.accessioned2020-03-26T19:33:45Z
dc.date.available2020-03-26T19:33:45Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose Spinal cord metastasis from rhabdomyosarcoma (RMS) is extremely rare, with three cases reported to date. Herein, we report an aggressive case of RMS of the infratemporal fossa who which developed spinal cord metastases during treatment. Case presentation A 6-year-old girl presented with an enlarging painless mass around her right ear for 3 months. An enhanced magnetic resonance imaging (MRI) revealed a 5 x x4 x x4.5 5 cm mass on her right infratemporal fossa. A tru-cut biopsy was performed, and histopathologic examination revealed the diagnosis of rhabdomyosarcoma. At the time of the diagnosis, cerebrospinal fluid cytology was negative for malignant cells. The patient underwent induction chemotherapy. There was minimal response to chemotherapy, and the patient underwent curative radiotherapy. However, by 12th fraction of RT, the patient developed a progressive weakness on her lower extremity. Spinal MRI revealed multiple gross masses in different parts of the spinal cord. The local radiotherapy was changed toas craniospinal radiotherapy. However, two 2 weeks after the completion of the RT, the patient developed sepsis and expired because of septic shock. Conclusion Parameningeal RMS is a peculiar subgroup of RMS, which needs an aggressive approach. Despite aggressive approach, meningeal spread is the most important cause of the treatment failure. We should keept in mind that during the treatment, there can be meningeal spread towards to either the brain or spinal cord; therefore, we should follow -up the patients closely from this aspect.en_US
dc.identifier.doi10.1007/s00381-016-3318-5en_US
dc.identifier.endpage847en_US
dc.identifier.issn0256-7040en_US
dc.identifier.issn1433-0350en_US
dc.identifier.issue5en_US
dc.identifier.pmid27957633en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage843en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00381-016-3318-5
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34778
dc.identifier.volume33en_US
dc.identifier.wosWOS:000403477000021en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofCHILDS NERVOUS SYSTEMen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectRadiotherapyen_US
dc.subjectRhabdomyosarcomaen_US
dc.subjectSpinal cord metastasesen_US
dc.titleAn aggressive parameningeal rhabdomyosarcoma with multiple spinal cord metastases: a case report and review of the literatureen_US
dc.typeReviewen_US

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