Increased cardiac troponin I concentration in diabetic ketoacidosis

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dc.contributor.authorAtabek, ME
dc.contributor.authorPirgon, O
dc.contributor.authorOran, L
dc.contributor.authorErkul, I
dc.contributor.authorKurtoglu, S
dc.date.accessioned2020-03-26T16:55:19Z
dc.date.available2020-03-26T16:55:19Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: To examine the hypothesis that diabetic ketoacidosis may be associated with some degree of induced injury to heart muscle, related either to acidosis or hyperglycemia. Methods: Nineteen diabetic patients with acute ketoacidosis and 19 healthy children were enrolled in this study. Cardiac troponin I (cTnI), creatine kinase (CK)-MB and myoglobin levels were analyzed soon after admission and after 24 h. Patients were subdivided into two groups according to blood pH. Results: At the time of admission, the diabetic patients had significantly higher values than the controls for cTnI (0.193 +/- 0.008 vs 0.176 +/- 0.006 ng/dl; p < 0.001), CK-MB (24.1 < 2.1 vs 22.7 < 1.2 U/l; p = 0.02), and myoglobin (85.5 < 7.4 vs 52.5 +/- 8.3 mug/dl; p < 0.001). The diabetic patients also had significantly higher values than the controls for CK-MB (24 2.1 vs 22.7 +/- 1.2 U/l; p = 0.02) and for myoglobin (78.5 +/- 2.5 vs 52.5 +/- 8.3 mug/dl; p < 0.001) at 24 h. cTnI had normalized in patients at 24 h. All parameters were significantly different between patients with pH greater than or equal to7.0 and patients with pH <7.0. In addition, serum cTnI levels correlated negatively. with blood pH (r = -0.57, p = 0.026) and HCO3- (r = -0.65, p = 0.008) in the patients with diabetic ketoacidosis on admission. Conclusion: Our findings suggest that diabetic ketoacidosis, particularly when severe, has a detrimental effect on the myocardium.en_US
dc.identifier.endpage1082en_US
dc.identifier.issn0334-018Xen_US
dc.identifier.issue8en_US
dc.identifier.pmid15379418en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1077en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19095
dc.identifier.volume17en_US
dc.identifier.wosWOS:000223528400006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFREUND PUBLISHING HOUSE LTDen_US
dc.relation.ispartofJOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISMen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcardiac troponin Ien_US
dc.subjectcreatine kinase-MBen_US
dc.subjectdiabetic ketoacidosisen_US
dc.subjectmyoglobinen_US
dc.subjectmyocardial injuryen_US
dc.titleIncreased cardiac troponin I concentration in diabetic ketoacidosisen_US
dc.typeArticleen_US

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