Essential oils of hedgenettles (Stachys inflata, S. lavandulifolia, and S. byzantina) have antioxidant, anti-Alzheimer, antidiabetic, and anti-obesity potential: A comparative study
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Date
2020
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier B.V.
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
Stachys species (hedgenettle or woundwort) are important medicinal plants known for their flavor and fragrance. They are widely consumed in Europe and Asia as aromatic herbal teas. In this work, essential oils (EOs) of three popular Stachys herbs namely Stachys inflata Benth., S. lavandulifolia Vahl., and S. byzantina K. Koch were investigated for their chemical composition, antioxidant activity, and health benefits. The major volatile components of S. inflata were identified as germacrene D (21.6 %) and ?-pinene (15.6 %). S. lavandulifolia contained mainly germacrene D (22.5 %) and ?-pinene (15.5 %) whereas S. byzantina showed hexahydrofarnesyl acetone (25.7 %) and valeranone (17.1 %) as major volatile constituents. EOs exhibited promising reducing power in cupric reducing antioxidant capacity (58?204 mg Trolox equivalents/g EO) and ferric reducing antioxidant power (32?104 mg Trolox equivalents/g EO) assays. Moreover, the metal chelating activity of EOs was determined from 15 to 36 mg EDTA equivalents/g EO. S. inflata showed anti-Alzheimer's disease effect through inhibition of cholinesterase enzymes (5.2–7.8 mg galantamine equivalents/g EO). All samples had a strong antidiabetic effect (?-glucosidase inhibition) with values ranging from 4.47 to 4.62 mmol acarbose equivalents/g EO. Also, remarkable anti-obesity (lipase inhibition with 88?159 mg orlistat equivalents/g EO) and anti-hyperpigmentation (tyrosinase inhibition with 24?35 mg kojic acid equivalents/g EO) potential were observed for Stachys EOs. These findings showed that EOs of hedgenettle (betony) plants could be employed in the preparation of formulations to be used in cosmetics, food, and pharmaceutical products due to their valuable antioxidant, neuroprotective, hypoglycemic, anti-obesity, and skin-care effects. © 2020 Elsevier B.V.
Description
Keywords
Anti-diabetes, Anti-obesity, Essential oil, Hedgenettle, Neuroprotective, Stachys
Journal or Series
Industrial Crops and Products
WoS Q Value
Q1
Scopus Q Value
Q1
Volume
145
