Essential oils of hedgenettles (Stachys inflata, S. lavandulifolia, and S. byzantina) have antioxidant, anti-Alzheimer, antidiabetic, and anti-obesity potential: A comparative study

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dc.contributor.authorBahadori, M. B.
dc.contributor.authorMaggi, F.
dc.contributor.authorZengin, Gökhan
dc.contributor.authorAsghari, B.
dc.contributor.authorEskandani, M.
dc.date.accessioned2020-03-26T20:20:47Z
dc.date.available2020-03-26T20:20:47Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractStachys species (hedgenettle or woundwort) are important medicinal plants known for their flavor and fragrance. They are widely consumed in Europe and Asia as aromatic herbal teas. In this work, essential oils (EOs) of three popular Stachys herbs namely Stachys inflata Benth., S. lavandulifolia Vahl., and S. byzantina K. Koch were investigated for their chemical composition, antioxidant activity, and health benefits. The major volatile components of S. inflata were identified as germacrene D (21.6 %) and ?-pinene (15.6 %). S. lavandulifolia contained mainly germacrene D (22.5 %) and ?-pinene (15.5 %) whereas S. byzantina showed hexahydrofarnesyl acetone (25.7 %) and valeranone (17.1 %) as major volatile constituents. EOs exhibited promising reducing power in cupric reducing antioxidant capacity (58?204 mg Trolox equivalents/g EO) and ferric reducing antioxidant power (32?104 mg Trolox equivalents/g EO) assays. Moreover, the metal chelating activity of EOs was determined from 15 to 36 mg EDTA equivalents/g EO. S. inflata showed anti-Alzheimer's disease effect through inhibition of cholinesterase enzymes (5.2–7.8 mg galantamine equivalents/g EO). All samples had a strong antidiabetic effect (?-glucosidase inhibition) with values ranging from 4.47 to 4.62 mmol acarbose equivalents/g EO. Also, remarkable anti-obesity (lipase inhibition with 88?159 mg orlistat equivalents/g EO) and anti-hyperpigmentation (tyrosinase inhibition with 24?35 mg kojic acid equivalents/g EO) potential were observed for Stachys EOs. These findings showed that EOs of hedgenettle (betony) plants could be employed in the preparation of formulations to be used in cosmetics, food, and pharmaceutical products due to their valuable antioxidant, neuroprotective, hypoglycemic, anti-obesity, and skin-care effects. © 2020 Elsevier B.V.en_US
dc.description.sponsorshipTabriz University of Medical Sciencesen_US
dc.description.sponsorshipThe authors are grateful for the financial support (grant No: 59536) granted by Vice Chancellor for Research (VCR) of Tabriz University of Medical Sciences (TUOMS), Tabriz, Iran . The authors moreover would like to acknowledge Miss. Soodeh Hassanzadeh for her kind assistance in the collection of the plant material.en_US
dc.identifier.doi10.1016/j.indcrop.2020.112089en_US
dc.identifier.issn0926-6690en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.indcrop.2020.112089
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38668
dc.identifier.volume145en_US
dc.identifier.wosWOS:000518865400103en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofIndustrial Crops and Productsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAnti-diabetesen_US
dc.subjectAnti-obesityen_US
dc.subjectEssential oilen_US
dc.subjectHedgenettleen_US
dc.subjectNeuroprotectiveen_US
dc.subjectStachysen_US
dc.titleEssential oils of hedgenettles (Stachys inflata, S. lavandulifolia, and S. byzantina) have antioxidant, anti-Alzheimer, antidiabetic, and anti-obesity potential: A comparative studyen_US
dc.typeArticleen_US

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