Binding interactions of niclosamide with serum proteins

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dc.contributor.authorMaltas, Esra
dc.date.accessioned2020-03-26T18:49:34Z
dc.date.available2020-03-26T18:49:34Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractA study of the binding of niclosamide (NC) to serum proteins such as human serum albumin, hemoglobin, and globulin was carried out using fluorescence and UV-visible spectroscopy. Interactions between NC and these proteins were estimated by Stern-Volmer and van't Hoff equations. The binding constants and the thermodynamic parameters, Delta H, Delta S, and Delta G at different temperatures were also determined by using these equations. Data showed that NC may exhibit a static quenching mechanism with all proteins. The thermodynamic parameters were calculated. Data showed that van der Waals interactions and hydrogen bonds are the main forces for human serum albumin and hemoglobin. Globulin, however, bound to NC via hydrophobic interaction. The spectral changes of synchronous fluorescence suggested that both the microenvironment of NC and the conformation of the proteins changed in relation to their concentrations during NC's binding. Copyright (C) 2014, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC. All rights reserved.en_US
dc.description.sponsorshipResearch Foundation of Selcuk University (BAP)Selcuk Universityen_US
dc.description.sponsorshipWe would like to thank the Research Foundation of Selcuk University (BAP) for financial support of this work.en_US
dc.identifier.doi10.1016/j.jfda.2014.03.004en_US
dc.identifier.endpage555en_US
dc.identifier.issn1021-9498en_US
dc.identifier.issue4en_US
dc.identifier.pmid28911473en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage549en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jfda.2014.03.004
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30639
dc.identifier.volume22en_US
dc.identifier.wosWOS:000346623500022en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFOOD & DRUG ADMINSTRATIONen_US
dc.relation.ispartofJOURNAL OF FOOD AND DRUG ANALYSISen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectFluorescence quenchingen_US
dc.subjectHuman serum albumin (HSA)en_US
dc.subjectNiclosamideen_US
dc.subjectStern-Volmer equationen_US
dc.subjectThermodynamic parametersen_US
dc.titleBinding interactions of niclosamide with serum proteinsen_US
dc.typeArticleen_US

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