Effectiveness of pentoxifylline on the cross-sectional area of intima media thickness and functions of the common carotid artery in adolescents with type 1 diabetes

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dc.contributor.authorAtabek, Mehmet Emre
dc.contributor.authorKurtoglu, Selim
dc.contributor.authorSelver, Beray
dc.contributor.authorBaykara, Murat
dc.date.accessioned2020-03-26T18:14:19Z
dc.date.available2020-03-26T18:14:19Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: The aim of the present study was to evaluate the effect of oral pentoxifylline on the cross-sectional area of intima media thickness (CSA-IMT) and functions of the common carotid artery, a marker of early atherosclerosis, in adolescents with type 1 diabetes. Patients and methods: Non-invasive ultrasonographic measurements were made in 56 type 1 diabetic patients. The diabetic patients were matched first in terms of age, diabetes duration, major cardiovascular risk factors, including anthropometric and metabolic parameters as well as ultrasonographic measurements, then one individual within each pair randomized into a pentoxifylline group and a placebo (control) group (i.e., 32 on pentoxifylline group and 24 on placebo). Pentoxifylline was administered for 6 months. We investigated the change of CSA-IMT, compliance, distensibility, diastolic wall stress (DWS), and incremental elastic modulus of the common carotid artery at 6 months after pentoxifylline. Results: In comparison of changes in common carotid artery measurements between the two groups, the pentoxifylline treatment group had significantly higher values than the controls for CSA-IMT (-2.6 +/- 0.1 vs. 0.7 +/- 0.4 mm(2), p=0.001) and for DWS (-0.38 +/- 0.02 vs. -0.05 +/- 0.05 mm Hgx10(2), p<0.001). In a multivariate regression model for all patients, being in pentoxifylline group was the best predictor of the change DWS (beta=-0.52, p<0.001). Conclusion: Our preliminary results suggest that pentoxifylline has an antiatherogenic action and might modulate risk factors for atherosclerosis in type 1 diabetes.en_US
dc.identifier.doi10.1515/JPEM.2011.199en_US
dc.identifier.endpage951en_US
dc.identifier.issn0334-018Xen_US
dc.identifier.issue11.12.2020en_US
dc.identifier.pmid22308846en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage945en_US
dc.identifier.urihttps://dx.doi.org/10.1515/JPEM.2011.199
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26384
dc.identifier.volume24en_US
dc.identifier.wosWOS:000300157700013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWALTER DE GRUYTER & COen_US
dc.relation.ispartofJOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISMen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcommon carotid arteryen_US
dc.subjectearly atherosclerosisen_US
dc.subjectpentoxifyllineen_US
dc.subjecttype 1 diabetesen_US
dc.titleEffectiveness of pentoxifylline on the cross-sectional area of intima media thickness and functions of the common carotid artery in adolescents with type 1 diabetesen_US
dc.typeArticleen_US

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