The effect of bupivacaine on compound action potential parameters of sciatic nerve fibers

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dc.contributor.authorDalkilic, N
dc.contributor.authorBariskaner, H
dc.contributor.authorDogan, N
dc.contributor.authorDemirel, I
dc.contributor.authorIlhan, B
dc.date.accessioned2020-03-26T16:55:32Z
dc.date.available2020-03-26T16:55:32Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to document the effects of the local anesthetic agent bupivacaine on individual fibers of peripheral nerve. To accomplish this objective, compound action potentials (CAPs) were recorded from isolated frog sciatic nerves treated with bupivacaine for seven individual concentration levels. Numerical and fast Fourier transform (FFT) analysis were performed on these recordings. The areas, latency periods, maximum and minimum derivatives, and power spectrums of the CAPs were computed. The results show that the area and the absolute values of maximum and minimum derivatives decrease linearly as bupivacaine concentration increases. The power spectrum of the CAPs, which resides in the 0-1000 Hz interval, initially shifts to higher frequencies then returns to lower frequency region again with increasing bupivacaine concentration. Due to this result, it is thought that bupivacaine inhibits nerve fibers in a dose-dependent manner. It primarily affects the fibers having the least myelin sheets (motor fibers), then it begins to depress the fast conducting (neurosensorial) fibers as the bupivacaine concentration increases, and finally blocks the unmyelinated C-fibers.en_US
dc.identifier.doi10.1080/00207450490257159en_US
dc.identifier.endpage16en_US
dc.identifier.issn0020-7454en_US
dc.identifier.issue1en_US
dc.identifier.pmid14660063en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://dx.doi.org/10.1080/00207450490257159
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19230
dc.identifier.volume114en_US
dc.identifier.wosWOS:000188008300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF NEUROSCIENCEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectbupivacaineen_US
dc.subjectcompound action potentialen_US
dc.subjectderivativeen_US
dc.subjectFFTen_US
dc.subjectFourier transformen_US
dc.subjectlocal anestheticen_US
dc.subjectnerveen_US
dc.titleThe effect of bupivacaine on compound action potential parameters of sciatic nerve fibersen_US
dc.typeArticleen_US

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