Differential diagnosis between secondary and tertiary hyperparathyroidism in a case of a giant-cell and brown tumor containing mass. Findings by Tc-99m-MDP, F-18-FDG PET/CT and (99)mTc-MIBI scans

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dc.contributor.authorGedik, Gonca Kara
dc.contributor.authorAta, Ozlem
dc.contributor.authorKarabagli, Pinar
dc.contributor.authorSari, Oktay
dc.date.accessioned2020-03-26T18:50:05Z
dc.date.available2020-03-26T18:50:05Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBrown tumor is one of the skeletal manifegtations of hyperparathyroidism. It is a benign but locally aggressive bone lesion and its differential diagnosis with giant cell containing skeletal tumors or metastases may be complicated. We present a male patient with chronic renal failure who was initially misdiagnosed as having a giant-cell rich neoplasm of bone in his right thumb. Diffusely increased fluorine-18 fluorodeoxyglucose (F-18-FDG) uptake in the axial and appendicular skeleton and multiple F-18-FDG avid lytic lesions suggesting multiple metastases were observed on the F-18-FDG positron emission tomography/computed tomography (PET/CT) scan. On the usual technetium-99m methylene diphosphonate (Tc-99m-MDP) bone scan we noticed diffusely increased uptake in the skeleton and two focuses with very much increased uptake, which suggested a metabolic bone disease rather than a multiple metastatic giant cell tumor or bone metastases. Additional investigation documentated increased levels of parathyroid hormone. Parathyroid hyperplasia was finally diagnosed with Tc-99m-methoxyisobutylisonitrile (MIBI) parathyroid scintigraphy. Fluorine-18-FDG avid lytic lesions were attributed to hyerparathyroidism associated brown tumors instead of multiple metastases. In conclusion, we present a patient with chronic renal insufficiency, who suffered from secondary and later from tertiary HPT with polyostotic brown tumors, which were best shown by the F-18-FDG PET/CT than by the Tc-99m-MDP or the Tc-99m-MIBI scans.en_US
dc.identifier.endpage217en_US
dc.identifier.issn1790-5427en_US
dc.identifier.issue3en_US
dc.identifier.pmid25397627en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage214en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30744
dc.identifier.volume17en_US
dc.identifier.wosWOS:000347437100013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHELLENIC SOC NUCLEAR MEDICINEen_US
dc.relation.ispartofHELLENIC JOURNAL OF NUCLEAR MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectGiant cells tumoren_US
dc.subjectBrown tumoren_US
dc.subjectHyperparathyroidismen_US
dc.subjectTertiary HPTen_US
dc.subjectPET/CT, Tc-99m-MDP and Tc-99m-MIBI scansen_US
dc.titleDifferential diagnosis between secondary and tertiary hyperparathyroidism in a case of a giant-cell and brown tumor containing mass. Findings by Tc-99m-MDP, F-18-FDG PET/CT and (99)mTc-MIBI scansen_US
dc.typeArticleen_US

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