Histological effects of zinc and melatonin on rat testes

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dc.contributor.authorTuncer, I
dc.contributor.authorSunar, F.
dc.contributor.authorToy, H.
dc.contributor.authorBaltaci, A. K.
dc.contributor.authorMogulkoc, R.
dc.date.accessioned2020-03-26T18:14:49Z
dc.date.available2020-03-26T18:14:49Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: The objective of this study is to examine the histological effects of zinc and melatonin, alone or in combination, on rat testes. Methods: For this purpose four study groups of ten Sprague-Dawley male rats were formed and treated for one month as follows: (1) Controls; (2) Rats injected with 3 mg/kg/day zinc, as zinc sulfate; (3) Rats injected with 3 mg/kg/day melatonin and (4) Rats injected with 3 mg/kg/day each zinc and melatonin. Results: After four weeks the rats treated with melatonin showed inhibited spermatogenesis, testicular tubular degeneration and necrosis, obstruction of tubular lumen and lymphocytic infiltration. The two zinc-treated groups showed no histological differences to controls but the melatonin-only group showed inhibited spermatogenetic activity, tubular degeneration and necrosis, as well as obstruction of tubule lumens and lymphocytic infiltration. Conclusion: The obtained results suggest that 4-week treatment with melatonin leads to histological and physiological impairments of testis and that zinc supplementation might offset these damaging effects (Tab. 2, Fig. 4, Ref. 12). Full Text in free PDF www.bmj.sk.en_US
dc.identifier.endpage427en_US
dc.identifier.issn0006-9248en_US
dc.identifier.issue8en_US
dc.identifier.pmid21863611en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage425en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26533
dc.identifier.volume112en_US
dc.identifier.wosWOS:000293049300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCOMENIUS UNIVen_US
dc.relation.ispartofBRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectzincen_US
dc.subjectmelatoninen_US
dc.subjecttestesen_US
dc.subjectraten_US
dc.titleHistological effects of zinc and melatonin on rat testesen_US
dc.typeArticleen_US

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