The influence of estradiol and progesterone and melatonin supplementation on TNF-alpha levels in ovariectomized and pinealectomized rats

Basit Öğe Kaydı
dc.contributor.authorOztekin, Esma
dc.contributor.authorMogulkoc, R.
dc.contributor.authorBaltaci, A. K.
dc.contributor.authorTiftik, A. A.
dc.date.accessioned2020-03-26T17:04:35Z
dc.date.available2020-03-26T17:04:35Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the effect of estradiol and progesterone and melatonin supplementation on TNF-alpha levels in ovariectomized and pinealectomized rats. The study was carried out on 42 adult, Spraque-Dawley strain female rats aged 6 months and weighing 200-250 grams. The rats were divided into 6 groups, each group contained 7 rats. Group 1: Sham-ovariectomized (Sham-Ovx), Group 2: Ovariectomized (Ovx), Group 3: Ovx and estradiol (E) and progesterone (P) supplemented (Ovx+E-P) group, Group 4: Ovx+E-P+Melatonin (M) supplemented group, Group 5: Ovx Pinealectomized (Pnx) group, Group 6: Ovx - Pnx+E-P supplemented group. Serum TNF-alpha levels were determined after 4 weeks application period. Group 6 (Ovx-Pnx+E-P) has the highest serum TNF-alpha compared with other groups while group 2 (ovariectomized), has the lowest levels (P < 0.001). Group 5 was higher than groups 1, 2, 3 and 4 (P < 0.001). The results of the study show that ovariectomy reduces the serum level of TNF-alpha, but estradiol and progesterone application prevents this reduction in ovariectomized rats. However, pinealectomy intensifies the increases in TNF-alpha levels in ovariectomized and estradiol and progesterone supplemented rats, whereas melatonin reduces TNF-alpha levels in ovariectomized rats.en_US
dc.identifier.doi10.1556/ABiol.57.2006.3.1en_US
dc.identifier.endpage281en_US
dc.identifier.issn0236-5383en_US
dc.identifier.issue3en_US
dc.identifier.pmid17048691en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage275en_US
dc.identifier.urihttps://dx.doi.org/10.1556/ABiol.57.2006.3.1
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20732
dc.identifier.volume57en_US
dc.identifier.wosWOS:000241053700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAKADEMIAI KIADOen_US
dc.relation.ispartofACTA BIOLOGICA HUNGARICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectovariectomyen_US
dc.subjectpinealectomyen_US
dc.subjectestradiol and progesterone applicationen_US
dc.subjectTNF-alpha raten_US
dc.titleThe influence of estradiol and progesterone and melatonin supplementation on TNF-alpha levels in ovariectomized and pinealectomized ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu