Acute-Phase Changes in Children Recovering from Minor Surgery

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dc.contributor.authorGünel, E.
dc.contributor.authorÇağlayan, O.
dc.contributor.authorÇağlayan, F.
dc.contributor.authorŞahin, T. K.
dc.date.accessioned2020-03-26T16:26:04Z
dc.date.available2020-03-26T16:26:04Z
dc.date.issued1998
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe metabolic response to surgical stress is a nonspecific increase in hepatic synthesis of some specialized acute-phase proteins and a decrease in plasma concentrations of visceral proteins following surgical trauma. This study was undertaken determine which specific proteins were the better clinical indices in monitoring the metabolic response to surgical stress in children recovering from minor surgery. Forty-four patients undergoing elective inguinal surgical procedures under general anesthesia were studied. Blood samples were collected preoperatively (-1) and at 1(+1) and 5(+5) days postoperatively to determine albumin (AL), Prealbumin (PA), C-reactive protein (CRP), and al-acid glycoprotein (AGP) values, and to calculate the prognostic inflammatory and nutritional index (PINI). Mean AL values were the same on all days. Mean PA +1 was significantly lower than PA -1 and PA +5 (P < 0.001). Median CRP +1 and mean AGP +1 values were significantly higher than median CRP -1 and mean AGP -1 (P < 0.0001), respectively. Although there was a decrease after postoperative day i, median CRP + 5 and mean AGP + 5 values were still significantly higher than preoperative values (P < 0.01 and P < 0.0001). Moreover, the median PINI + 1 was also greater than PINI -1 and PINI +5 (P < 0.0001), but the median PINI+5 was significantly higher than PINI -1 (P < 0.01). Median percent changes of PINI values were significantly higher than those of the other parameters from both preoperatively to postoperative day I and preoperatively to postoperative day 5. Although several specific proteins (AL, PA, CRP, and AGP) have been evaluated as indicators of the acute metabolic response, we suggest that the PINI is more valuable for reflecting the response to surgical stress in patients recovering from minor surgery.en_US
dc.identifier.citationGünel, E., Çağlayan, O., Çağlayan, F., Şahin, T. K., (1998). Acute-Phase Changes in Children Recovering from Minor Surgery. Pediatric Surgery International, 14(3), 199-201. Doi.10.1007/s003830050486
dc.identifier.doi10.1007/s003830050486en_US
dc.identifier.endpage201en_US
dc.identifier.issn0179-0358en_US
dc.identifier.issn1437-9813en_US
dc.identifier.issue3en_US
dc.identifier.pmid9880748en_US
dc.identifier.startpage199en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s003830050486
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16745
dc.identifier.volume14en_US
dc.identifier.wosWOS:000077658900014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGünel, E.
dc.institutionauthorÇağlayan, O.
dc.institutionauthorÇağlayan, F.
dc.institutionauthorŞahin, T. K.
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofPediatric Surgery Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectsurgical stressen_US
dc.subjectvisceral proteinen_US
dc.subjectacute-phase proteinen_US
dc.subjectchildhooden_US
dc.titleAcute-Phase Changes in Children Recovering from Minor Surgeryen_US
dc.typeArticleen_US

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