The mechanisms of the direct vascular effects of fentanyl on isolated human saphenous veins in vitro

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dc.contributor.authorSahin, AE
dc.contributor.authorDuman, A
dc.contributor.authorAtalik, EK
dc.contributor.authorOgun, CO
dc.contributor.authorSahin, TK
dc.contributor.authorErol, A
dc.contributor.authorOzergin, U
dc.date.accessioned2020-03-26T16:58:16Z
dc.date.available2020-03-26T16:58:16Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: The purpose of this study was to determine the mechanism of the direct effects of fentanyl on human veins in vitro. Design: In vitro, prospective with repeated measures. Setting: University research laboratory. Interventions: Dose-response curves were obtained for cumulative doses of fentanyl (10(-9)-10(-5) mol/L) on saphenous vein strips precontracted with (10(-6) mol/L) 5-hydroxytryptamine incubated with either naloxone (10(-4) mol/L), N omega-nitroL-arginine-methyl ester (L-NAME) (10(-4) mol/L), indomethacin (10(-5) mol/L), glibenclamide (10-4 mol/L), tetraethylammonium (10(-4) mol/L), or ouabain (10(-5) mol/L). Vein strips were also exposed to a Ca++-free solution and 0.1 mmol/L of ethylene glycol-bis-(b-aminoethylether) N,N '-tetraacetic acid; 5-hydroxytryptamine (10(-6) mol/L) was added to the bath before cumulative Ca++ (10(-4)-10(-2) mol/L). The same procedure was repeated in the presence of fentanyl (10-6, 3 x 10-6, or 10-5 mol/L) (p < 0.05 = significant). Measurements and Main Results: Preincubation of vein strips with naloxone, L-NAME, or indomethacin did not influence the relaxant responses to fentanyl (p > 0.05). Tetraethylammonium, glibenclamide, and ouabain reduced the relaxation response to fentanyl (p < 0.05). A stepwise increase in tension was recorded with cumulative doses of Ca++ (p < 0.05). Conclusions: The present results show that fentanyl causes vasodilatation via both endothelium- and opioid receptor-independent mechanisms in the human saphenous vein. The relaxant effects of fentanyl are probably via activation of K+ channel and Na+K+-adenosine trisphosphatase and inhibition of Ca++ channel. (c) 2005 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1053/j.jvca.2005.01.031en_US
dc.identifier.endpage200en_US
dc.identifier.issn1053-0770en_US
dc.identifier.issn1532-8422en_US
dc.identifier.issue2en_US
dc.identifier.pmid15868528en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage197en_US
dc.identifier.urihttps://dx.doi.org/10.1053/j.jvca.2005.01.031
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19929
dc.identifier.volume19en_US
dc.identifier.wosWOS:000228754400013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B SAUNDERS CO-ELSEVIER INCen_US
dc.relation.ispartofJOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectfentanylen_US
dc.subjectvascular effectsen_US
dc.subjectK+ channelsen_US
dc.subjectnitric oxideen_US
dc.subjectindomethacinen_US
dc.subjectsaphenous veinsen_US
dc.subjectcoronary blood flowen_US
dc.subjectcoronary artery surgeryen_US
dc.titleThe mechanisms of the direct vascular effects of fentanyl on isolated human saphenous veins in vitroen_US
dc.typeArticleen_US

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