Survivin and cycline D1 expressions are associated with malignant potential in mucinous ovarian neoplasms

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dc.contributor.authorKanter, Mehmet
dc.contributor.authorTuran, Gulay
dc.contributor.authorUsta, Ceyda
dc.contributor.authorUsta, Akin
dc.contributor.authorEsen, H. Hasan
dc.contributor.authorTavli, Lema
dc.contributor.authorCelik, Cetin
dc.date.accessioned2020-03-26T19:26:41Z
dc.date.available2020-03-26T19:26:41Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe most prevalent malignant ovarian neoplasms are epithelial ovarian cancers which is the most common cause of death among all gynecologic malignancies and a result of complex interaction of multiple oncogenes and tumor suppressor genes. The aim of this study was to evaluate expression of survivin and cycline D1 biomarkers in mucinous ovarian neoplasms and their correlations with clinicopathological variables in mucinous ovarian cancers. We analyzed pathological specimens of 98 patients with benign (n = 34), borderline (n = 22) and malignant (n = 42) mucinous ovarian neoplasms. Immunohistochemical analysis was performed on formalin-fixed paraffin-embedded specimens. Immunohistochemical analysis revealed that survivin and cyclin D1 expressions were located primarily in the nucleus of ovarian tumor cells and relatively weaker cytoplasmic staining. Survivin expression was significantly higher in malignant tumors (88.1 %) than those found in borderline (18.2 %) and benign tumors (8.8 %) (p < 0.001). Similarly, higher cyclin D1 expression was observed in malignant tumors (100 %) compared to borderline (36.4 %) and benign tumors (5.9 %) (p < 0.001). Expression of all biomarkers analyzed significantly and gradually increased from benign to borderline and borderline to malignant mucinous tumors. In terms of clinicopathological variables, tumor grade, FIGO stage and lymph node methastasis were associated with the expression of both biomarkers. Whereas age exhibited no different correlations in mucinous ovarian cancers. The expressions of survivin and cycline D1 are positively correlated with the malignant potential of mucinous ovarian neoplasms.en_US
dc.identifier.doi10.1007/s10735-016-9661-8en_US
dc.identifier.endpage152en_US
dc.identifier.issn1567-2379en_US
dc.identifier.issn1567-2387en_US
dc.identifier.issue2en_US
dc.identifier.pmid26815661en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage145en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s10735-016-9661-8
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34041
dc.identifier.volume47en_US
dc.identifier.wosWOS:000373119000007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofJOURNAL OF MOLECULAR HISTOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSurvivinen_US
dc.subjectCycline D1en_US
dc.subjectMucinousen_US
dc.subjectOvarian neoplasmsen_US
dc.subjectImmunohistochemical analysisen_US
dc.titleSurvivin and cycline D1 expressions are associated with malignant potential in mucinous ovarian neoplasmsen_US
dc.typeArticleen_US

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