Is the low AMH level associated with the risk of cardiovascular disease in obese pregnants?

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dc.contributor.authorGuler, Basak
dc.contributor.authorÖzler, Sibel
dc.contributor.authorKadioglu, Nezaket
dc.contributor.authorOzkan, Eda
dc.contributor.authorGungoren, Merve Sibel
dc.contributor.authorCelen, Sevki
dc.date.accessioned2020-03-26T20:14:58Z
dc.date.available2020-03-26T20:14:58Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractOur aim was to investigate whether Antimullerian Hormone (AMH), complete blood count (CBC), Homeostasis model assessment (HOMA-IR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and weight gain have any diagnostic value for the prediction of cardiovascular disease (CVD) in obese and non-obese pregnant patients. A prospective, case-control study was carried out, including 187 patients (93 obese, and 94 non-obese). CVD risk for each patient was evaluated according to the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA). A multivariate logistic regression model was used to identify the independent risk factors of CVD in obese and non-obese patients. The obese patients had significantly lower levels of AMH when compared to the non-obese ones (p = .002). Insulin, HOMA-IR, HbA1c, and SBP were significantly higher in obese patients than non-obese ones (p < .001, p < .001 and p = .001, respectively). Age, SBP, and decreased AMH levels had significantly associated with risk factors of CVD in the obese group (p = .001, p = .002, and p = .049, respectively). Our study suggests that decreased AMH levels, increased age, and SBP are associated with CVD in obese patients. AMH may be used to evaluate CVD risk in advanced aged, obese patients.IMPACT STATEMENT What is already known on this subject? Obesity is one of the most common medical complications of pregnancy. Obesity increases maternal complications such as preeclampsia, caesarean rate, cardiovascular disease, obesity, and diabetes after pregnancy; and neonatal complications including macrosomia, hypoglycaemia, hyperbilirubinemia, delivery trauma, shoulder dystocia, and adult-onset obesity, and diabetes. Obese patients have lower serum AMH levels. What the results of this study add? A significant relationship between AMH levels and CVD risk in obese pregnant women was observed.en_US
dc.identifier.citationGüler, B., Özler, S., Kadıoğlu, N., Özkan, E., Güngören, M. S., Çelen, Ş. (2020). Is The Low AMH Level Associated With The Risk Of Cardiovascular Disease İn Obese Pregnants?. Journal Of Obstetrics And Gynaecology, 40,(7), 912-917.
dc.identifier.doi10.1080/01443615.2019.1672633en_US
dc.identifier.issn0144-3615en_US
dc.identifier.issn1364-6893en_US
dc.identifier.pmid31809625en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://dx.doi.org/10.1080/01443615.2019.1672633
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37963
dc.identifier.wosWOS:000501113000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzler, Sibel
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS INCen_US
dc.relation.ispartofJOURNAL OF OBSTETRICS AND GYNAECOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAntimullerian hormoneen_US
dc.subjectobese pregnanten_US
dc.subjectcardiovascular disease risken_US
dc.titleIs the low AMH level associated with the risk of cardiovascular disease in obese pregnants?en_US
dc.typeArticleen_US

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