Intravenous N-acetylcysteine Plus High-dose Hydration Versus High-dose Hydration and Standard Hydration for the Prevention of Contrast-induced Nephropathy: CASİS-A Multicenter Prospective Controlled Trial

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dc.contributor.authorKoc, Fatih
dc.contributor.authorOzdemir, Kurtulus
dc.contributor.authorKaya, Mehmet Gungor
dc.contributor.authorDogdu, Orhan
dc.contributor.authorVatankulu, Mehmet Akif
dc.contributor.authorAyhan, Selim
dc.contributor.authorErkorkmaz, Unal
dc.contributor.authorSonmez, Osman
dc.contributor.authorAygul, Meryem Ulku
dc.contributor.authorKalay, Nihat
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorKarabag, Turgut
dc.contributor.authorAlihanoglu, Yusuf
dc.contributor.authorGunebakmaz, Ozgur
dc.date.accessioned2020-03-26T18:30:44Z
dc.date.available2020-03-26T18:30:44Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Contrast-induced nephropathy (CIN) is a leading cause of acute renal failure and affects mortality and morbidity. We investigated the efficacy of prophylactic intravenous (IV) N-acetylcysteine (NAC) and hydration for the prevention of CIN in patients with mild to moderate renal dysfunction who are undergoing coronary angiography and/or percutaneous coronary intervention (PCI). Methods: A total of 220 patients who had mild to moderate renal dysfunction with serum creatinine (SCr) >= 1.1 mg/dL or creatinine clearance <= 60 mL/min were randomized in 3 groups: 80 patients were assigned to IV NAC plus high-dose hydration with normal saline, 80 patients to only high-dose hydration with normal saline and 60 patients to standard hydration with normal saline (control group). The primary end point was the alteration of SCr level. The secondary end point was the development of CIN after the procedure. Results: SCr levels changed the least in the NAC plus high-hydration group (P=0.004). The rate of the CIN in the NAC plus high-dose hydration group was also lower than the high-dose hydration group (P=0.006). No significant differences in the primary and secondary end points were found between high-dose hydration and control group. Conclusion: The results of this study suggest that NAC plus high-dose hydration was superior to high-dose hydration alone as well as standard hydration for the protection of renal functions in patients with mild to moderate renal dysfunction who are undergoing coronary angiography and/or PCI. High-dose hydration without NAC was not better than standard hydration alone.en_US
dc.identifier.citationKoc, F., Ozdemir, K., Kaya, M. G., Dogdu, O., Vatankulu, M. A., Ayhan, S., Erkorkmaz, U., Sonmez, O., Aygul, M. U., Kalay, N., Kayrak, M., Karabag, T., Alihanoglu, Y., Gunebakmaz, O., (2012). Intravenous N-acetylcysteine Plus High-dose Hydration Versus High-dose Hydration and Standard Hydration for the Prevention of Contrast-induced Nephropathy: CASİS-A Multicenter Prospective Controlled Trial. International Journal of Cardiology, (155), 418-423. Doi:10.1016/j.ijcard.2010.10.041
dc.identifier.doi10.1016/j.ijcard.2010.10.041en_US
dc.identifier.endpage423en_US
dc.identifier.issn0167-5273en_US
dc.identifier.issn1874-1754en_US
dc.identifier.pmid21106264en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage418en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.ijcard.2010.10.041
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28154
dc.identifier.volume155en_US
dc.identifier.wosWOS:000300840000021en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorOzdemir, Kurtulus
dc.institutionauthorVatankulu, Mehmet Akif
dc.institutionauthorAyhan, Selim
dc.institutionauthorSonmez, Osman
dc.institutionauthorAygul, Meryem Ulku
dc.institutionauthorKayrak, Mehmet
dc.institutionauthorKarabag, Turgut
dc.institutionauthorAlihanoglu, Yusuf
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectContrast induced nephropathyen_US
dc.subjectIntravenous N-acetylcysteineen_US
dc.subjectHigh-dose hydrationen_US
dc.titleIntravenous N-acetylcysteine Plus High-dose Hydration Versus High-dose Hydration and Standard Hydration for the Prevention of Contrast-induced Nephropathy: CASİS-A Multicenter Prospective Controlled Trialen_US
dc.typeArticleen_US

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