Evidence for an Association Between Type 1 Diabetes and Premature Carotid Atherosclerosis in Childhood

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dc.contributor.authorAtabek, M. E.
dc.contributor.authorPirgon, O.
dc.contributor.authorKurtoglu, S.
dc.contributor.authorİmamoğlu, H.
dc.date.accessioned2020-03-26T17:03:32Z
dc.date.available2020-03-26T17:03:32Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAcute phase proteins have been suggested to be increased in patients with type 1 diabetes. The aim of this study was to evaluate the relationship between serum C-reactive protein (CRP) and intima-media thickness (IMT) and functions of the common carotid artery (CCA) in children and adolescents with type 1 diabetes. Serum CRP levels were measured in 65 children and adolescents with diabetes (33 girls and 32 boys; mean age, 12.7 +/- 3.8 years; range, 7-18; duration of diabetes, 6.9 +/- 3.6 years). Age and diabetes duration, as well as major cardiovascular risk factors including anthropometric and metabolic parameters, were matched between girls and boys. The relations of serum CRP levels to CCA structure and functions were measured by ultrasonography as IMT, cross-sectional compliance, cross-sectional distensibility, diastolic wall stress (DWS), and incremental elastic modulus (IEM). There was no significant difference for serum CRP levels between girls and boys (3.7 +/- 1.3 vs 3.2 +/- 0.4 mg/L; p > 0.05). CRP was positively correlated with IMT (r = 0.49, p = 0.001), IEM (r = 0.24, p = 0.05), DWS (r = 0.58, p < 0.001), and body mass index (BMI) (r = 0.28, p = 0.05). In a multivariate regression model, we included CRP and metabolic and anthropometric parameters such as duration of diabetes, HbA1c, BMI, waist:hip ratio, age, and systolic and diastolic blood pressure as independent variables in the model for CCA structure and functions. CRP emerged as an independent correlation for mean IMT (beta = 0.51, p < 0.001) and DWS (beta = 0.61, p < 0.001). According to our findings, CRP was associated with CCA structure and functions in children and adolescents with type 1 diabetes.en_US
dc.identifier.citationAtabek, M. E., Pirgon, O., Kurtoglu, S., İmamoğlu, H., (2006). Evidence for an Association Between Type 1 Diabetes and Premature Carotid Atherosclerosis in Childhood. Pediatric Cardiology, 27(4), 428-433. Doi: 10.1007/s00246-006-1199-1
dc.identifier.doi10.1007/s00246-006-1199-1en_US
dc.identifier.endpage433en_US
dc.identifier.issn0172-0643en_US
dc.identifier.issue4en_US
dc.identifier.pmid16633845en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage428en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00246-006-1199-1
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20489
dc.identifier.volume27en_US
dc.identifier.wosWOS:000239728400007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAtabek, M. E.
dc.institutionauthorPirgon, O.
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjecttype 1 diabetesen_US
dc.subjectcommon carotid arteryen_US
dc.subjectC-reactive proteinen_US
dc.subjectatherosclerosisen_US
dc.titleEvidence for an Association Between Type 1 Diabetes and Premature Carotid Atherosclerosis in Childhooden_US
dc.typeArticleen_US

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