Diuretics, plasma brain natriuretic peptide and chronic obstructive pulmonary disease

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dc.contributor.authorKanat, F.
dc.contributor.authorVatansev, H.
dc.contributor.authorTeke, T.
dc.date.accessioned2020-03-26T17:17:14Z
dc.date.available2020-03-26T17:17:14Z
dc.date.issued2007
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Brain natriuretic peptide (BNP) is associated with increased myocardial stretching. This study aims to assess the effect of mild diuretics on plasma BNP levels in patients with an acute exacerbation of chronic obstructive pulmonary disease (COPD) who have high plasma concentrations of BNP. Methods: Thirty consecutive patients with an acute exacerbation of COPD without any clinical evidence of cor pulmonale who had elevated plasma BNP concentrations (group 1) and 15 patients with stable COPD as controls (group 2) participated in this study. A mild diuretic treatment in addition to the standard treatment for an acute attack of COPD was randomised to 15 patients in group 1 (group 1A). The remaining patients in group 1 only took standard treatment for acute COPD exacerbation (group 1B). Plasma BNP concentrations were measured on admission and repeated on the 5th and 10th days. Results: There was a significant decrease in plasma BNP concentrations, more striking in group 1A than 1B. Both in group 1A and 1B, the fall in plasma BNP concentrations was independent of either presence or absence of right ventricular dysfunction on echo evaluation. Conclusion: Adding mild diuretics to the standard treatment for an acute attack of COPD may rapidly reduce plasma BNP levels in COPD patients with acute exacerbations who have high plasma BNP levels without any clinical evidence of cor pulmonale.en_US
dc.identifier.endpage300en_US
dc.identifier.issn0300-2977en_US
dc.identifier.issn1872-9061en_US
dc.identifier.issue8en_US
dc.identifier.pmid17890789en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage296en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/21321
dc.identifier.volume65en_US
dc.identifier.wosWOS:000250192000005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVAN ZUIDEN COMMUNICATIONSen_US
dc.relation.ispartofNETHERLANDS JOURNAL OF MEDICINEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectbrain natriuretic peptideen_US
dc.subjectchronic obstructive pulmonary diseaseen_US
dc.subjectcor pulmonaleen_US
dc.subjectdiureticsen_US
dc.titleDiuretics, plasma brain natriuretic peptide and chronic obstructive pulmonary diseaseen_US
dc.typeArticleen_US

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