8-Isoprostane and Coenzyme Q10 Levels in Patients with Metabolic Syndrome

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dc.contributor.authorErcan, Humeyra
dc.contributor.authorKiyici, Aysel
dc.contributor.authorMarakoglu, Kamile
dc.contributor.authorOncel, Mufide
dc.date.accessioned2020-03-26T19:22:54Z
dc.date.available2020-03-26T19:22:54Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Metabolic syndrome has become an important health problem, which involves obesity, hyper-lipidemia, insulin resistance, and high blood pressure values. The components of metabolic syndrome are all suggested as independent cardiovascular disease risk factors along with high mortality and morbidity rates accompanied by many organ and system complications. Objective: We aimed to determine 8-isoprostane (8-IsoP) and coenzyme Q10 (CoQ10) levels in patients with metabolic syndrome and healthy individuals and demonstrate whether there was any relation between these parameters and metabolic syndrome criteria. Materials and Methods: A total of 30 patients (10 male, 20 female) with metabolic syndrome and 20 age-matched healthy individuals (9 male, 11 female) were involved in the study. Body mass index, waist and hip circumferences, systolic and diastolic blood pressures and serum glucose, triglyceride, total cholesterol, high-density lipoprotein cholesterol, insulin, HbA1c, 8-IsoP and CoQ10 levels, and homeostasis model assessment of insulin resistance indexes of all participants were determined. Results: 8-IsoP levels were significantly increased in metabolic syndrome compared to healthy individuals (P = 0.003), however, there was no significant difference between groups for CoQ10 levels. 8-IsoP levels were positively correlated with waist circumference (r = 0.303, P=0.032), diastolic blood pressure (r = 0.337, P = 0.017), systolic blood pressure (r = 0.329, P = 0.020) values and total cholesterol levels (r = 0.354, P=0.012). Conclusion: We can suggest that the levels of 8-IsoP, which is an indicator of the oxidative stress, increase in metabolic syndrome and this can be associated with high blood pressure and visceral adiposity, which are the components of metabolic syndrome.en_US
dc.description.sponsorshipScientific Research Projects Unit of Selcuk UniversitySelcuk University [BAP09202038]en_US
dc.description.sponsorshipThis study was carried out with the grant from the Scientific Research Projects Unit of Selcuk University (BAP09202038).en_US
dc.identifier.doi10.1089/met.2016.0011en_US
dc.identifier.endpage321en_US
dc.identifier.issn1540-4196en_US
dc.identifier.issn1557-8518en_US
dc.identifier.issue6en_US
dc.identifier.pmid27171014en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage318en_US
dc.identifier.urihttps://dx.doi.org/10.1089/met.2016.0011
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33170
dc.identifier.volume14en_US
dc.identifier.wosWOS:000380807400007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMARY ANN LIEBERT, INCen_US
dc.relation.ispartofMETABOLIC SYNDROME AND RELATED DISORDERSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.title8-Isoprostane and Coenzyme Q10 Levels in Patients with Metabolic Syndromeen_US
dc.typeArticleen_US

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