Association Between Apolipoprotein E Polymorphism and Subclinic Atherosclerosis in Patients with Type 1 Diabetes Mellitus

Basit Öğe Kaydı
dc.contributor.authorAtabek, Mehmet Emre
dc.contributor.authorOzkul, Yusuf
dc.contributor.authorEklioglu, Beray Selver
dc.contributor.authorKurtoglu, Selim
dc.contributor.authorBaykara, Murat
dc.date.accessioned2020-03-26T18:24:00Z
dc.date.available2020-03-26T18:24:00Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: The most important cause of morbidity and mortality in type 1 diabetes mellitus (DM) is atherosclerosis. Apolipoprotein E (Apo E) polymorphism is accused of being the genetic risk factor for atherosclerosis. The aim of the present study was to determine which Apo E polymorphism was related to atherosclerosis in patients with type 1 DM. Methods: Seventy-four patients with type 1 DM were enrolled in the study. Age, diabetes duration, daily insulin dose, microalbuminuria, and major cardiovascular risk factors including anthropometric and metabolic parameters were assessed in each patient. Non-invasive ultrasonographic measurements were also performed. For determination of Apo E genotype, DNA was extracted from venous blood from all subjects using standard methods. Apo E genotyping was performed using a PCR-restriction fragment-length polymorphism assay. Results: Systolic blood pressure and carotid artery intima-media thickness (CA-IMT) were increased in subjects with E4/E4 polymorphism. According to univariate analysis, when adjusted for all risk factors, genotypes did not differ for total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglycerides (p>0.05). However, E3/E3, E3/E4 and E4/E4 genotypes were found to be associated with an increase in CA-IMT (p<0.001). Conclusions: Our results suggest that the polymorphism associated with atherosclerosis in type1 DM is Apo E4/E4.en_US
dc.identifier.doi10.4274/jcrpe.521en_US
dc.identifier.endpage13en_US
dc.identifier.issn1308-5727en_US
dc.identifier.issn1308-5735en_US
dc.identifier.issue1en_US
dc.identifier.pmid22394699en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage8en_US
dc.identifier.urihttps://dx.doi.org/10.4274/jcrpe.521
dc.identifier.urihttps://hdl.handle.net/20.500.12395/27770
dc.identifier.volume4en_US
dc.identifier.wosWOS:000209012500002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTURKISH PEDIATRIC ENDOCRINOLOGY & DIABETES SOCIETYen_US
dc.relation.ispartofJOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGYen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAtherosclerosisen_US
dc.subjectapolipoprotein Een_US
dc.subjectcarotid artery intima-media thicknessen_US
dc.subjecttype 1 diabetesen_US
dc.titleAssociation Between Apolipoprotein E Polymorphism and Subclinic Atherosclerosis in Patients with Type 1 Diabetes Mellitusen_US
dc.typeBook Chapteren_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu