Effects of Chronic and Acute Zinc Supplementation on Myocardial Ischemia-Reperfusion Injury in Rats

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dc.contributor.authorOzyildirim, Serhan
dc.contributor.authorBaltaci, Abdulkerim Kasim
dc.contributor.authorSahna, Engin
dc.contributor.authorMogulkoc, Rasim
dc.date.accessioned2020-03-26T19:35:19Z
dc.date.available2020-03-26T19:35:19Z
dc.date.issued2017
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe present study aims to explore the effects of chronic and acute zinc sulfate supplementation on myocardial ischemia-reperfusion injury in rats. The study registered 50 adult male rats which were divided into five groups in equal numbers as follows: group 1, normal control; group 2, sham; group 3, myocardial ischemia reperfusion (My/IR): the group which was fed on a normal diet and in which myocardial I/R was induced; group 4, myocardial ischemia reperfusion + chronic zinc: (5 mg/kg i.p. zinc sulfate for 15 days); and group 5, myocardial ischemia reperfusion + acute zinc: the group which was administered 15 mg/kg i.p. zinc sulfate an hour before the operation and in which myocardial I/R was induced. The collected blood and cardiac tissue samples were analyzed using spectrophotometric method to determine levels of MDA, as an indicator of tissue injury, and GSH, as an indicator of antioxidant activity. The highest plasma and heart tissue MDA levels were measured in group 3 (p < 0.05). Group 5 had lower MDA values than group 3, while group 4 had significantly lower MDA values than groups 3 and 5 (p < 0.05). The highest erythrocyte GSH values were found in group 4 (p < 0.05). Erythrocyte GSH values in group 5 were higher than those in group 3 (p < 0.05). The highest GSH values in heart tissue were measured in group 4 (p < 0.05). The results of the study reveal that the antioxidant activity inhibited by elevated oxidative stress in heart ischemia reperfusion in rats is restored partially by acute zinc administration and markedly by chronic zinc supplementation.en_US
dc.description.sponsorshipScientific Research Projects Coordinatorship of Selcuk University (SUBAPK)Selcuk University [12202033]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Coordinatorship of Selcuk University (SUBAPK; project no. 12202033).en_US
dc.identifier.doi10.1007/s12011-016-0903-0en_US
dc.identifier.endpage70en_US
dc.identifier.issn0163-4984en_US
dc.identifier.issn1559-0720en_US
dc.identifier.issue1en_US
dc.identifier.pmid27909864en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage64en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s12011-016-0903-0
dc.identifier.urihttps://hdl.handle.net/20.500.12395/35034
dc.identifier.volume178en_US
dc.identifier.wosWOS:000403072900009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHUMANA PRESS INCen_US
dc.relation.ispartofBIOLOGICAL TRACE ELEMENT RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMyocardial ischemia reperfusionen_US
dc.subjectAcute and chronic zinc supplementationen_US
dc.subjectAntioxidant activityen_US
dc.titleEffects of Chronic and Acute Zinc Supplementation on Myocardial Ischemia-Reperfusion Injury in Ratsen_US
dc.typeArticleen_US

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