The Impact of Body Mass Index on Radiotherapy Technique in Patients With Early-Stage Endometrial Cancer A Single-Center Dosimetric Study

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dc.contributor.authorYavas, Guler
dc.contributor.authorYavas, Cagdas
dc.contributor.authorKerimoglu, Ozlem Secilmis
dc.contributor.authorCelik, Cetin
dc.date.accessioned2020-03-26T18:58:38Z
dc.date.available2020-03-26T18:58:38Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: We aimed to evaluate the impact of body mass index on radiotherapy (RT) technique in patients with early-stage endometrial cancer. Materials and Methods: Twenty-seven consecutive patients were included in the study and divided into 3 groups with respect to their body mass index (normal weight, 18.5Y24.9 kg/m(2); overweight, 25-29.9 kg/m(2); obese, 30-39.9 kg/m(2)). Treatment plans using field-in-field (FIF) and 3-dimesional conformal RT (3D-CRT) were compared for the doses in the planning target volume (PTV), organs-at-risk (OAR) volumes, dose homogeneity index, and monitor unit counts required for the treatment. Results: The FIF technique was superior to 3D-CRT with respect to the maximum and mean doses received by OAR and dose homogeneity index values. The subgroup analyses revealed that the maximum dose received by the right femur and the mean doses received by the rectum and bladder were significantly reduced only in obese patients (Ps = 0.021, 0.008, and 0.008, respectively). The FIF technique significantly reduced the PTV volumes irradiated with greater than 105% of the prescribed dose (P < 0.001). The volumes of bowel and bone marrow receiving more than the prescribed dose of 30 Gy were significantly reduced only in obese patients (Ps = 0.025 and 0.043, respectively). The volumes of bladder, bowel, and bone marrow receiving more than the prescribed dose of 45 Gy were significantly reduced in only obese patients (Ps = 0.011, 0.011, and 0.008, respectively). Conclusions: Considering the lower maximum doses in OAR and PTV, we demonstrate the FIF technique to be more advantageous than 3D-CRT during adjuvant RT for early-stage endometrial cancer patients. This advantage is more prominent in obese patients. Therefore, FIF technique represents an effective pelvic RT treatment option for obese patients in clinics that do not have access to or prefer an alternative to intensity-modulated RT.en_US
dc.identifier.doi10.1097/IGC.0000000000000298en_US
dc.identifier.endpage1615en_US
dc.identifier.issn1048-891Xen_US
dc.identifier.issn1525-1438en_US
dc.identifier.issue9en_US
dc.identifier.pmid25275659en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1607en_US
dc.identifier.urihttps://dx.doi.org/10.1097/IGC.0000000000000298
dc.identifier.urihttps://hdl.handle.net/20.500.12395/31211
dc.identifier.volume24en_US
dc.identifier.wosWOS:000344611800015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLIPPINCOTT WILLIAMS & WILKINSen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCERen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBody mass indexen_US
dc.subjectDose-volume histogramsen_US
dc.subjectEndometrial canceren_US
dc.subjectObesityen_US
dc.subjectRadiotherapyen_US
dc.titleThe Impact of Body Mass Index on Radiotherapy Technique in Patients With Early-Stage Endometrial Cancer A Single-Center Dosimetric Studyen_US
dc.typeArticleen_US

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